ArticlePLoS pathogens2011
The next opportunity in anti-malaria drug discovery: the liver stage.
Article in PLoS pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Harnessing cholesterol uptake of malaria parasites for therapeutic applications.EMBO molecular medicine · 2024Article
- Pre-gelation staining expansion microscopy for visualisation of the Plasmodium liver stage.Journal of cell science · 2023Article
- Preliminary Assessment of Intramuscular Depot of Lipid-Based Decoquinate Formulation for Long-Term Chemoprophylaxis of Malaria.Pharmaceutics · 2022Article
- Preparation of Decoquinate Solid Dispersion by Hot-Melt Extrusion as an Oral Dosage Form Targeting Liver-StageAntimicrobial agents and chemotherapy · 2022Article
- Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12).ACS omega · 2022Article
- Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.ACS infectious diseases · 2021Article
- Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.Scientific reports · 2021Article
- Disrupting Plasmodium UIS3-host LC3 interaction with a small molecule causes parasite elimination from host cells.Communications biology · 2020Article
- Article
- Current therapies and future possibilities for drug development against liver-stage malaria.The Journal of clinical investigation · 2016Review
- High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.ACS infectious diseases · 2016Article
- Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification.Biomarker research · 2016Review
- In silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitors.Journal of computer-aided molecular design · 2015Article
- Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.Bioorganic & medicinal chemistry · 2014Article
- Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Traffic (Copenhagen, Denmark) · 2014Article
- Chemical interrogation of the malaria kinome.Chembiochem : a European journal of chemical biology · 2014Article
- Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).Journal of medicinal chemistry · 2014Article
- Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.ACS medicinal chemistry letters · 2014Article
- Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period.Malaria journal · 2014Article
- Antimalarial drug discovery - approaches and progress towards new medicines.Nature reviews. Microbiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.