ArticleIntensive care medicine2012
Acquired von Willebrand syndrome in patients with extracorporeal life support (ECLS).
Article in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04456894 (Importance of Monitoring Primary Hemostasis Pathology in Patients on Extracorporeal Membrane Oxygenation), which is not on this map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Importance of Monitoring Primary Hemostasis Pathology in Patients on Extracorporeal Membrane Oxygenation (ECMO) During Lung Transplantation
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Efficacy of venoarterial extracorporeal membrane oxygenation with and without intra-aortic balloon pump in adult cardiogenic shock.Frontiers in cardiovascular medicine · 2024Pooled it
- Platelets and extra-corporeal membrane oxygenation in adult patients: a systematic review and meta-analysis.Intensive care medicine · 2020Pooled it
- Platelet Phenotype and Function in the Setting of Pediatric Extracorporeal Membrane Oxygenation (ECMO): A Systematic Review.Frontiers in cardiovascular medicine · 2019Pooled it
- Hemostasis, coagulation and thrombin in venoarterial and venovenous extracorporeal membrane oxygenation: the HECTIC study.Scientific reports · 2021Trial
- Clinical and Functional Outcomes Following Repeat VA-ECMO in Adults: A Propensity Score-Matched Comparative Study.Journal of clinical medicine · 2026Article
- Acquired von Willebrand syndrome in a patient with rectal adenocarcinoma: a case report and review of the literature.Journal of medical case reports · 2026Review
- Hemocompatibility of Emergency Bypass System versus Permanent Life Support extracorporeal membrane oxygenation in a propensity score-matched cohort: analysis of hematologic trajectories and transfusion requirements.Journal of Yeungnam medical science · 2026Article
- Critical hematological parameters in bleeding during extracorporeal membrane oxygenation support.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Is Antithrombin Supplementation Effective in Suppressing ECMO Circuit Thrombosis in Sepsis?Juntendo medical journal · 2025Review
- Comparative study of flow rate- and material-dependent human plasma protein adsorption on oxygenator membranes and heat exchanger materials.Frontiers in cardiovascular medicine · 2025Article
- Association Between Cerebral Microbleeds and Neurological Outcomes in Patients Who Underwent Extracorporeal Membrane Oxygenation.Journal of the American Heart Association · 2024Article
- Upper gastrointestinal bleeding on veno-arterial extracorporeal membrane oxygenation support.Annals of intensive care · 2024Article
- Definitions of major bleeding for predicting mortality in critically ill adult patients who survived 24 hours while supported with peripheral veno-arterial extracorporeal membrane oxygenation for cardiogenic shock: a comparative historical cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Impact of Additional Administration of von Willebrand Factor Concentrates to Thrombocyte Transfusion in Perioperative Bleeding in Cardiac Surgery.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Article
- Observational
- Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.Thrombosis and haemostasis · 2023Article
- Comparison of Blood and Blood Product Transfusion in COVID-19 and Non-COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation for Severe Respiratory Failure.Journal of clinical medicine · 2023Article
- Bleeding and thrombotic events in post-cardiotomy extracorporeal life support.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
- Review
- Haematological Trends and Transfusion during Adult Extracorporeal Membrane Oxygenation: A Single Centre Study.Journal of clinical medicine · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExtracorporeal life support (ECLS) is used for patients with refractory heart failure with or without respiratory failure. This temporary support is provided by blood pumps which are connected to large vessels. Bleeding episodes are a typical complication in patients with ECLS. Recently, several studies illustrated that acquired von Willebrand syndrome (AVWS) can contribute to bleeding tendencies in patients with long-term ventricular assist devices (VAD). AVWS is characterized by loss of the high molecular weight (HMW) multimers of von Willebrand factor (VWF) as a result of high shear stress and leads to impaired binding of VWF to platelets and to subendothelial matrix. Since ECLS and VAD share several features, we investigated patients with ECLS for AVWS.
methodsWe analyzed 32 patients with ECLS and 19 of them without support. To diagnose AVWS, ratios of ristocetin cofactor activity (VWF:RCo) and collagen binding capacity (VWF:CB) to VWF antigen (VWF:Ag) were employed in conjunction with multimeric analysis.
resultsReduced VWF:RCo/VWF:Ag ratios were identified in 28 ECLS patients. Furthermore, VWF:CB/VWF:Ag ratios were decreased in 31 patients. HMW multimers of VWF were missing in the same 31 patients. Thus, 31 of 32 ECLS patients presented with AVWS. Twenty-two of the 32 patients suffered from bleeding complications. Without support, AVWS was not detectable in any analyzed patient.
conclusionOur data indicate that AVWS is a typical disorder in patients with ECLS. We hypothesize that AVWS could contribute to aggravation of bleeding tendencies in ECLS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.