ArticleJournal of molecular evolution2011
Selection-driven divergence after gene duplication in Arabidopsis thaliana.
Article in Journal of molecular evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Structure, function, regulation, evolution, and therapeutic implications of PARP14.Genes & development · 2026Review
- Functional Diversification and the Plant Secondary Cell Wall.Journal of molecular evolution · 2023Review
- SpartaABC: a web server to simulate sequences with indel parameters inferred using an approximate Bayesian computation algorithm.Nucleic acids research · 2017Article
- Concerted Divergence after Gene Duplication in Polycomb Repressive Complexes.Plant physiology · 2017Article
- Hybrid incompatibility caused by an epiallele.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism.DNA repair · 2014Article
- Article
- The Arabidopsis Kinome: phylogeny and evolutionary insights into functional diversification.BMC genomics · 2014Article
- Spatiotemporal seed development analysis provides insight into primary dormancy induction and evolution of the Lepidium delay of germination1 genes.Plant physiology · 2013Article
- Article
- Complex patterns of divergence among green-sensitive (RH2a) African cichlid opsins revealed by Clade model analyses.BMC evolutionary biology · 2012Article
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2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplications are one of the most important mechanisms for the origin of evolutionary novelties. Even though various models of the fate of duplicated genes have been established, current knowledge about the role of divergent selection after gene duplication is rather limited. In this study, we analyzed sequence divergence in response to neo- and subfunctionalization of segmentally duplicated genes in the genome of Arabidopsis thaliana. We compared the genomes of A. thaliana and the poplar Populus trichocarpa to identify orthologous pairs of genes and their corresponding inparalogs. Maximum-likelihood analyses of the nonsynonymous and synonymous substitution rate ratio [Formula: see text] of pairs of A. thaliana inparalogs were used to detect differences in the evolutionary rates of protein coding sequences. We analyzed 1,924 A. thaliana paralogous pairs and our results indicate that around 6.9% show divergent ω values between the lineages for a fraction of sites. We observe an enrichment of regulatory sequences, a reduced level of co-expression and an increased number of substitutions that can be attributed to positive selection based on an McDonald-Kreitman type of analysis. Taken together, these results show that selection after duplication contributes substantially to gene novelties and hence functional divergence in plants.
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