ReviewCellular and molecular life sciences : CMLS2011
Epithelial homeostasis and the underlying molecular mechanisms in the gut of the insect model Drosophila melanogaster.
Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Kismet/CHD7/CHD8 affects gut microbiota, mechanics, and the gut-brain axis in Drosophila melanogaster.Biophysical journal · 2025Article
- The Role of Gut Microbiota in Shaping Immune Responses in Tephritidae Fruit Fly and Prospective Implications for Management.Neotropical entomology · 2025Review
- Insect Models in Nutrition Research.Biomolecules · 2022Review
- Excreted secreted products from the parasitic nematode Steinernema carpocapsae manipulate the Drosophila melanogaster immune response.Scientific reports · 2022Article
- Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster.Nature ecology & evolution · 2022Article
- The legacy of larval infection on immunological dynamics over metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract.Cell communication and signaling : CCS · 2017Review
- Organ-to-Organ Communication: AFrontiers in cell and developmental biology · 2017Review
- Intestinal regeneration as an insect resistance mechanism to entomopathogenic bacteria.Current opinion in insect science · 2016Review
- Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Drosophila anti-nematode and antibacterial immune regulators revealed by RNA-Seq.BMC genomics · 2015Article
- Resistance to Innate Immunity Contributes to Colonization of the Insect Gut by Yersinia pestis.PloS one · 2015Article
- Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice.PloS one · 2015Article
- The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism.Cell host & microbe · 2014Article
- Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer.Frontiers in cellular and infection microbiology · 2014Review
- Host-microbe interactions in the gut of Drosophila melanogaster.Frontiers in physiology · 2013Review
- Review
- Caudal is a negative regulator of the Anopheles IMD pathway that controls resistance to Plasmodium falciparum infection.Developmental and comparative immunology · 2013Article
- Hemocyte density increases with developmental stage in an immune-challenged forest caterpillar.PloS one · 2013Article
- Endosymbiotic bacteria in insects: guardians of the immune system?Frontiers in physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insects mostly develop on decaying and contaminated organic matter and often serve as vectors of biologically transmitted diseases by transporting microorganisms to the plant and animal hosts. As such, insects are constantly ingesting microorganisms, a small fraction of which reach their epithelial surfaces, mainly their digestive tract, where they can establish relationships ranging from symbiosis to mutualism or even parasitism. Understanding the tight physical, genetic, and biochemical interactions that takes place between intestinal epithelia and either resident or infectious microbes has been a long-lasting objective of the immunologist. Research in this field has recently been re-vitalized with the development of deep sequencing techniques, which allow qualitative and quantitative characterization of gut microbiota. Interestingly, the recent identification of regenerative stem cells in the Drosophila gut together with the initial characterization of Drosophila gut microbiota have opened up new avenues of study aimed at understanding the mechanisms that regulate the dialog between the Drosophila gut epithelium and its microbiota of this insect model. The fact that some of the responses are conserved across species combined with the power of Drosophila genetics could make this organism model a useful tool to further elucidate some aspects of the interaction occurring between the microbiota and the human gut.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.