ArticleNeurochemical research2012
Altered biochemical parameters in saliva of pediatric attention deficit hyperactivity disorder.
Article in Neurochemical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Oxidative Stress and ADHD: A Meta-Analysis.Journal of attention disorders · 2015Pooled it
- Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit Hyperactivity Disorder.International journal of clinical practice · 2022Trial
- Review
- Alterations in Striatal Architecture and Biochemical Markers' Levels During Postnatal Development in the Rat Model of an Attention Deficit/Hyperactivity Disorder (ADHD).International journal of molecular sciences · 2024Article
- Age-related changes in the architecture and biochemical markers levels in motor-related cortical areas of SHR rats-an ADHD animal model.Frontiers in molecular neuroscience · 2024Article
- Competition and stereotypic behavior in Thoroughbred horses: The value of saliva as a diagnostic marker of stress.PloS one · 2024Article
- The Effect of Drug Use, Body Mass Index and Blood Pressure on Oxidative Stress Levels in Children and Adolescents with Attention Deficit and Hyperactivity Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Mitochondrial Dysfunction in Attention Deficit Hyperactivity Disorder.The Eurasian journal of medicine · 2022Article
- Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency.Nutrients · 2021Review
- Potential Novel Therapies for Neurodevelopmental Diseases Targeting Oxidative Stress.Oxidative medicine and cellular longevity · 2021Review
- Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder.Antioxidants (Basel, Switzerland) · 2020Review
- Magnesium, Iron, Zinc, Copper and Selenium Status in Attention-Deficit/Hyperactivity Disorder (ADHD).Molecules (Basel, Switzerland) · 2020Review
- Effect of Vitamin D and Magnesium Supplementation on Behavior Problems in Children with Attention-Deficit Hyperactivity Disorder.International journal of preventive medicine · 2020Article
- Peripheral Mitochondrial DNA Copy Number is Increased in Korean Attention-Deficit Hyperactivity Disorder Patients.Frontiers in psychiatry · 2019Article
- Rationale for Dietary Antioxidant Treatment of ADHD.Nutrients · 2018Review
- The Role of Nutritional Supplements in the Treatment of ADHD: What the Evidence Says.Current psychiatry reports · 2017Review
- Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.Clinical epigenetics · 2017Article
- Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder.Noro psikiyatri arsivi · 2016Article
- Increased oxidative stress in children with attention deficit hyperactivity disorder.Redox report : communications in free radical research · 2016Article
- Evaluation of Oxidative Metabolism in Child and Adolescent Patients with Attention Deficit Hyperactivity Disorder.Psychiatry investigation · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is one of the common causes in etiopathogenesis of attention deficit hyperactivity disorder (ADHD). Hence, the salivary levels of protein thiols, ceruloplasmin, magnesium and pseudocholinesterase were estimated in children with ADHD. The symptoms of ADHD were identified using Conner's rating and DSM IV criteria. Saliva was collected and assessed for the levels of protein thiols, ceruloplasmin, magnesium and pseudocholinesterase, spectrophotometrically. It was also checked for pH and the flow rate was noted down. There was a significant increase (P < 0.001) in the salivary protein thiols and pseudocholinesterase levels in ADHD children when compared to controls. Ceruloplasmin levels did not show any significant change. Magnesium levels were significantly decreased (P < 0.001) in cases when compared to controls. Further, a receiver operating characteristic curve for validity of the biochemical parameters in saliva of ADHD children indicated a sensitivity and specificity above 90% for protein thiols and magnesium values. Our study shows that protein thiols, magnesium, and pseudocholinesterase might have a role in the pathogenesis of ADHD and saliva can be effectively used as a non-invasive tool for evaluation of such children.
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