ArticleJournal of neuro-oncology2012
Pediatric high grade glioma of the spinal cord: results of the HIT-GBM database.
Article in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pediatric-type high-grade glioma of the spinal cord in the molecular era: institutional case series and updated systematic review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- A Nomogram for Predicting Overall Survival of Patients With Primary Spinal Cord Glioblastoma.Neurospine · 2024Article
- Primary Intramedullary Spinal High-Grade Glioma: A Case Series with Review of Literature.South Asian journal of cancer · 2024Article
- Pediatric spinal cord diffuse midline glioma, H3 K27-altered with intracranial and spinal leptomeningeal spread: A case report.The neuroradiology journal · 2022Article
- Demographic and prognostic factors of optic nerve astrocytoma: a retrospective study of surveillance, epidemiology, and end results (SEER).BMC cancer · 2021Article
- Advanced Magnetic Resonance Imaging in Pediatric Glioblastomas.Frontiers in neurology · 2021Review
- Pediatric primary high-grade spinal glioma: a National Cancer Database analysis of current patterns in treatment and outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Treatment patterns of children with spine and spinal cord tumors: national outcomes and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Article
- Glioblastoma multiforme in conus medullaris with intracranial metastasis after postoperative adjuvant therapy.Medicine · 2017Article
- Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma.Nature reviews. Cancer · 2014Review
- Cerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma.British journal of cancer · 2013Article
- Paediatric spinal glioblastoma: case report and review of therapeutic strategies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- Paediatric and adult malignant glioma: close relatives or distant cousins?Nature reviews. Clinical oncology · 2012Review
- Pediatric high grade glioma: a review and update on tumor clinical characteristics and biology.Frontiers in oncology · 2012Article
- Pediatric spinal high-grade glioma in the pediatric precision oncology registry INFORM: Identification of potential therapeutic targets.Neuro-oncology advancesArticle
- Application evaluation of intraoperative ultrasound combined with neuro electrophysiological detection in the spinal cord glioma surgery.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about pediatric spinal cord high grade gliomas (SCHGG) beyond their dismal prognosis. Here, we analyzed the HIT-GBM(®) database for the influence of surgical resection on survival. Between 1991 and 2010 the HIT-GBM group collected data from European children diagnosed with high grade glioma. Patients with the following inclusion criteria were analyzed in this study: astrocytic histology, WHO grade III or IV, age at diagnosis <18 years, and tumor localized to the spinal cord. 28 patients (mean age 11.28 years, 14 male) with primary SCHGG were identified. The tumor sizes were measured by the span across adjacent vertebrae and varied greatly (range: 1-20, median: 4). Histology was classified as WHO grade III in 15 and grade IV in 13 tumors. Of note, the four largest tumors identified were WHO grade III. Surgery was classified as complete resection (n = 6), subtotal resection (STR) (n = 7), partial resection (n = 12) or biopsy only (n = 3). 27 patients received chemotherapy, 22 of which also received radiation. With the mean follow-up time of 2.88 (SD ± 2.95) years, 14 patients were still alive resulting in a median overall survival of 2.5 years (SE ± 1.6). The positive prognostic indicators for overall survival were: age younger than 5 years (P = 0.047), WHO grade III (P = 0.046), absence of necrosis (P = 0.025) and gross total resection (GTR) (P = 0.012). The prognosis of SCHGG might not be as miserable as generally assumed. GTR is of benefit. Larger data sets and meta-analysis are necessary to identify patient sub-groups.
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