ArticleJournal of magnetic resonance imaging : JMRI2011
Manganese-enhanced MRI reveals multiple cellular and vascular layers in normal and degenerated retinas.
Article in Journal of magnetic resonance imaging : JMRI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience.Frontiers in neural circuits · 2019Review
- Manganese Enhanced MRI for Use in Studying Neurodegenerative Diseases.Frontiers in neural circuits · 2018Review
- Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.Frontiers in aging neuroscience · 2018Review
- Risk factors for poor outcomes in patients with open-globe injuries.Clinical ophthalmology (Auckland, N.Z.) · 2016Article
- Laminar specific detection of APP induced neurodegeneration and recovery using MEMRI in an olfactory based Alzheimer's disease mouse model.NeuroImage · 2015Article
- The distribution of Mn2+ in rabbit eyes after topical administration for manganese-enhanced MRI.International journal of clinical and experimental pathology · 2015Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- Manganese-enhanced MRI (MEMRI) via topical loading of Mn(2+) significantly impairs mouse visual acuity: a comparison with intravitreal injection.NMR in biomedicine · 2014Article
- Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
- Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats.Experimental eye research · 2012Article
- MRI study of subconjunctival and intravitreal injections.Journal of pharmaceutical sciences · 2012Article
- Review: magnetic resonance imaging techniques in ophthalmology.Molecular vision · 2012Review
- Lamina-specific anatomic magnetic resonance imaging of the human retina.Investigative ophthalmology & visual science · 2011Article
- Magnetic resonance imaging of vascular oxygenation changes during hyperoxia and carbogen challenges in the human retina.Investigative ophthalmology & visual science · 2011Article
- Layer-specific anatomical, physiological and functional MRI of the retina.NMR in biomedicine · 2008Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo use manganese-enhanced magnetic resonance imaging (MEMRI) at 25 × 25 × 800 μm(3) to image different retinal and vascular layers in the rat retinas. MATERIALS AND
methodsManganese-chloride was injected intraocularly in normal (n = 5) and Royal College of Surgeons (RCS, an model of photoreceptor degeneration) (n = 5) rats at postnatal day 90. MEMRI at 4.7 T was performed 24 hours later. MRI was repeated following intravenous Gd-DTPA in the same animals to highlight the vasculatures. Layer assignment and thickness were compared to histology.
resultsMEMRI 24 hours after intravitreal manganese-chloride injection revealed seven bands of alternating hyper- and hypointensities, corresponding histologically to the ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, photoreceptor-segment layer, and choroidal vascular layer. Intravenous Gd-DTPA-which does not cross the blood-retinal barrier and the retinal pigment epithelium-further enhanced the two layers bounding the retina, corresponding to the retinal and choroidal vascular layers, but not the avascular outer nuclear layer and the photoreceptor-segment layer. MEMRI of the RCS retinas revealed the loss of the outer plexiform layer, outer nuclear layer, and photoreceptor-segment layer. Histological analysis corroborated the MRI laminar assignments and thicknesses.
conclusionLamina-specific retinal structures neurodegenerative changes to structure in retinal diseases can be detected using MEMRI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.