ArticleNeuromolecular medicine2011
Renalase gene polymorphisms in patients with type 2 diabetes, hypertension and stroke.
Article in Neuromolecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Association of Renalase SNPs rs2296545 and rs2576178 with the Risk of Hypertension: A Meta-Analysis.PloS one · 2016Pooled it
- Effect of salt intake and potassium supplementation on serum renalase levels in Chinese adults: a randomized trial.Medicine · 2014Trial
- Cardiovascular risk assessed using the SCORE system and blood renalase concentration in the Polish subpopulation of the PURE study.Scientific reports · 2026Article
- Phosphodiesterase Inhibition and Immunotropic Activity of Dipyridamole Dynamic Derivatives.Current issues in molecular biology · 2025Article
- Renalase alleviates salt-induced kidney necroptosis and inflammation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- The early diagnostic value of serum renalase level in diabetic kidney disease and diabetic macroangiopathy: a retrospective case-control study.Therapeutic advances in chronic disease · 2024Article
- Coexistence of Cardiovascular Risk Factors and Blood Renalase Concentration.International journal of molecular sciences · 2023Article
- Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults.Frontiers in cardiovascular medicine · 2022Article
- Renalase gene Glu37Asp polymorphism affects susceptibility to diabetic retinopathy in type 2 diabetes mellitus.Acta diabetologica · 2021Article
- A Fifth of the Protein World: Rossmann-like Proteins as an Evolutionarily Successful Structural unit.Journal of molecular biology · 2021Article
- The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.Disease markers · 2021Article
- Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Renalase Protects against Renal Fibrosis by Inhibiting the Activation of the ERK Signaling Pathways.International journal of molecular sciences · 2017Article
- Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.PloS one · 2017Article
- Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients.PloS one · 2017Article
- Article
- Rs10887800 renalase gene polymorphism is associated with an increased risk of coronary artery disease in hemodialyzed patients.International urology and nephrology · 2016Article
- Renalase attenuates hypertension, renal injury and cardiac remodelling in rats with subtotal nephrectomy.Journal of cellular and molecular medicine · 2016Article
- Renalase Gene rs2576178 Polymorphism in Hemodialysis Patients: Study in Bosnia and Herzegovina.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Age influence on renalase and catecholamines concentration in hypertensive patients, including maintained dialysis.Clinical interventions in aging · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study was to investigate the involvement of renalase gene polymorphisms in hypertension in type 2 diabetes patients. A total of 892 patients and 400 controls were genotyped with three SNPs in the renalase gene. The C allele of rs2296545 SNP was associated with hypertension (P < 0.01). For rs2576178 SNP, frequencies in hypertensive patients differed from controls, but not from normotensive patients. For rs10887800 SNP, the differences in the G allele frequencies were observed in hypertensive patients with stroke, with 66% of patients being GG homozygotes. To confirm observed association we later genotyped 130 stroke patients without diabetes. The OR for risk allele was 1.79 (95% CI 1.33-2.41). In conclusion, the renalase gene polymorphism was associated with hypertension in type 2 diabetes patients. The most interesting result is a strong association of the rs10887800 polymorphism with stroke in patients with and without diabetes. The G allele of this polymorphism might thus be useful in identifying diabetes patients at increased risk of stroke.
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