ArticleMolecular and cellular biology1990
Regulation of the Discoidin I gamma gene in Dictyostelium discoideum: identification of individual promoter elements mediating induction of transcription and repression by cyclic AMP.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
- Proteomic and microarray analyses of the Dictyostelium Zak1-GSK-3 signaling pathway reveal a role in early development.Eukaryotic cell · 2007Article
- IfkA, a presumptive eIF2 alpha kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound size.BMC developmental biology · 2003Article
- gdt1, a new signal transduction component for negative regulation of the growth-differentiation transition in Dictyostelium discoideum.Molecular biology of the cell · 2000Article
- Antagonistic effects of signal transduction by intracellular and extracellular cAMP on gene regulation in Dictyostelium.Molecular biology of the cell · 1996Article
- PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium.Experientia · 1995Review
- Genetic and physiologic modulation of the prestarvation response in Dictyostelium discoideum.Molecular biology of the cell · 1995Article
- Use of a transactive regulatory mutant of Dictyostelium discoideum in a eucaryotic expression system.Nucleic acids research · 1993Article
- Transcriptional regulation by folate: inducible gene expression in Dictyostelium transformants during growth and early development.Nucleic acids research · 1992Article
- Inducible expression of calmodulin antisense RNA in Dictyostelium cells inhibits the completion of cytokinesis.Molecular biology of the cell · 1992Article
- A developmentally regulated gene encodes the dictyostelium homolog of yeast ribosomal protein S4 and mammalian LLRep3 proteins.Nucleic acids research · 1991Article
- Translational control of discoidin lectin expression in drsA suppressor mutants of Dictyostelium discoideum.Molecular and cellular biology · 1991Article
- Developmental regulation of the alpha-mannosidase gene in Dictyostelium discoideum: control is at the level of transcription and is affected by cell density.Molecular and cellular biology · 1991Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We dissected the promoter of the developmentally induced and cyclic AMP-repressed discoidin I gamma gene and identified a sequence element essential for developmental induction. Transfer of the element to an inactive heterologous promoter demonstrated that this sequence is sufficient to confer expression in axenically growing cells and to induce gene activity in development after growth on bacteria. A 16-base-pair sequence within this element was shown to be sufficient for induction in the discoidin promoter context and was used to reactivate different truncated promoter constructs. This led to the localization of an element necessary for down regulation of gene expression by extracellular cyclic AMP.
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