ArticleMolecular and cellular biology1990
Enhanced translation and increased turnover of c-myc proteins occur during differentiation of murine erythroleukemia cells.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 80 citations in OpenAlex.
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- Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme's stability under stress conditions.Biochemical and biophysical research communications · 2012Article
- Down-regulation of Myc is essential for terminal erythroid maturation.The Journal of biological chemistry · 2010Article
- Inhibition of monkeypox virus replication by RNA interference.Virology journal · 2009Article
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- Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc.Leukemia · 2002Article
- Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294.Molecular and cellular biology · 2001Article
- Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.Genes & development · 2000Article
- A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells.Molecular and cellular biology · 2000Article
- c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis.Molecular and cellular biology · 2000Article
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- Expression of the c-myc proto-oncogene is essential for HIV-1 infection in activated T cells.The Journal of experimental medicine · 1999Article
- The polyadenylation inhibitor cordycepin (3'dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levels.Oncogene · 1999Article
- Induction of programmed cell death by parvovirus H-1 in U937 cells: connection with the tumor necrosis factor alpha signalling pathway.Journal of virology · 1998Article
- A single nucleotide change in the c-myc internal ribosome entry segment leads to enhanced binding of a group of protein factors.Nucleic acids research · 1998Article
- Function of the c-Myc antagonist Mad1 during a molecular switch from proliferation to differentiation.Molecular and cellular biology · 1997Article
- Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins.Molecular and cellular biology · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To determine whether regulation of c-myc proteins occurs during the differentiation of murine erythroleukemia cells, we examined c-myc protein synthesis and accumulation throughout dimethyl sulfoxide (DMSO)- or hypoxanthine-induced differentiation. c-myc protein expression exhibited an overall biphasic reduction, with an initial concomitant decrease in c-myc RNA, protein synthesis, and protein accumulation early during the commitment phase. However, as the mRNA and protein levels recovered, c-myc protein synthesis levels dissociated from the levels of c-myc mRNA and protein accumulation. This dissociation appears to result from unusual translational and posttranslational regulation during differentiation. Translational enhancement was suggested by the observation that relatively high levels of c-myc proteins were synthesized from relatively moderate levels of c-myc RNA. This translational enhancement was not observed with c-myb. Under certain culture conditions, we also observed a change in the relative synthesis ratio of the two independently initiated c-myc proteins. Posttranslational regulation was evidenced by a dramatic postcommitment decrease in the accumulated c-myc protein levels despite relatively high levels of c-myc protein synthesis. This decrease corresponded with a twofold increase in the turnover of c-myc proteins. The consequence of this regulation was that the most substantial decrease in c-myc protein accumulation occurred during the postcommitment phase of differentiation. This result supports the hypothesis that the reduction in c-myc at relatively late times is most important for completion of murine erythroleukemia cell terminal differentiation.
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