ArticleProceedings of the National Academy of Sciences of the United States of America2011
Improving peppermint essential oil yield and composition by metabolic engineering.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed.
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- Formation mechanism of glandular trichomes involved in the synthesis and storage of terpenoids in lavender.BMC plant biology · 2023Article
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- Chromosome-level genome assembly of Mentha longifolia L. reveals gene organization underlying disease resistance and essential oil traits.G3 (Bethesda, Md.) · 2022Article
- Exploring the Relationship between Trichome and Terpene Chemistry in Chrysanthemum.Plants (Basel, Switzerland) · 2022Article
- Genetic Manipulation of Biosynthetic Pathways in Mint.Frontiers in plant science · 2022Review
- Multi-omics analysis of the bioactive constituents biosynthesis of glandular trichome in Perilla frutescens.BMC plant biology · 2021Article
- Transcriptome Analysis of Light-Regulated Monoterpenes Biosynthesis in Leaves ofPlants (Basel, Switzerland) · 2021Article
- In vitro cultivation of tansy (Tanacetum vulgare L.): a tool for the production of potent pharmaceutical agents.Protoplasma · 2021Article
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- Metabolic Engineering of the Native Monoterpene Pathway in Spearmint for Production of Heterologous Monoterpenes Reveals Complex Metabolism and Pathway Interactions.International journal of molecular sciences · 2020Article
- Volatile Profile of Mead Fermenting Blossom Honey and Honeydew Honey with or withoutMolecules (Basel, Switzerland) · 2020Article
- Crop Wild Relatives as Germplasm Resource for Cultivar Improvement in Mint (Frontiers in plant science · 2020Review
- Improving Phenolic Total Content and Monoterpene inInternational journal of molecular sciences · 2019Article
- Harnessing evolutionary diversification of primary metabolism for plant synthetic biology.The Journal of biological chemistry · 2019Review
- Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action.Molecules (Basel, Switzerland) · 2019Review
- Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid Chemical Diversity.Frontiers in plant science · 2019Review
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Peppermint (Mentha × piperita L.) was transformed with various gene constructs to evaluate the utility of metabolic engineering for improving essential oil yield and composition. Oil yield increases were achieved by overexpressing genes involved in the supply of precursors through the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway. Two-gene combinations to enhance both oil yield and composition in a single transgenic line were assessed as well. The most promising results were obtained by transforming plants expressing an antisense version of (+)-menthofuran synthase, which is critical for adjusting the levels of specific undesirable oil constituents, with a construct for the overexpression of the MEP pathway gene 1-deoxy-D-xylulose 5-phosphate reductoisomerase (up to 61% oil yield increase over wild-type controls with low levels of the undesirable side-product (+)-menthofuran and its intermediate (+)-pulegone). Elite transgenic lines were advanced to multiyear field trials, which demonstrated consistent oil yield increases of up to 78% over wild-type controls and desirable effects on oil composition under commercial growth conditions. The transgenic expression of a gene encoding (+)-limonene synthase was used to accumulate elevated levels of (+)-limonene, which allows oil derived from transgenic plants to be recognized during the processing of commercial formulations containing peppermint oil. Our study illustrates the utility of metabolic engineering for the sustainable agricultural production of high quality essential oils at a competitive cost.
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