Trial reportAmerican journal of physiology. Heart and circulatory physiology2011
Sex differences in carotid baroreflex control of arterial blood pressure in humans: relative contribution of cardiac output and total vascular conductance.
Trial report in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 88 citations in OpenAlex.
- Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation.The Journal of physiology · 2022Trial
- Ventilatory response to hypercapnia is increased after 4 h of head down bed rest.Scientific reports · 2021Trial
- Factors Influencing the Cardiovascular Response to Subanesthetic Ketamine: A Randomized, Placebo-Controlled Trial.The international journal of neuropsychopharmacology · 2017Trial
- Influence of the Metaboreflex on Pulmonary Vascular Capacitance in Heart Failure.Medicine and science in sports and exercise · 2016Trial
- Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women.American journal of physiology. Heart and circulatory physiology · 2026Article
- Vascular limitations in blood pressure regulation with age in women: Insights from exercise and acute cardioselective β-blockade.Experimental physiology · 2025Article
- Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Sex differences in conditioned pain modulation effects and its associations with autonomic nervous system activities in healthy, younger individuals: a pilot study.Pain reports · 2024Article
- Sympathetic control of the coronary circulation during trigeminal nerve stimulation in humans.European journal of applied physiology · 2023Article
- Habitual physical activity improves vagal cardiac modulation and carotid baroreflex function in elderly women.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Effects of resistance training on baroreflex sensitivity function in healthy males.Journal of physical therapy science · 2022Article
- Arterial Baroreflex Inhibits Muscle Metaboreflex Induced Increases in Effective Arterial Elastance: Implications for Ventricular-Vascular Coupling.Frontiers in physiology · 2022Article
- Ventricular-Vascular Uncoupling in Heart Failure: Effects of Arterial Baroreflex-Induced Sympathoexcitation at Rest and During Exercise.Frontiers in physiology · 2022Article
- Orthostatic responses in Caucasian, South Asian, and Middle Eastern women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Augmented Respiratory-Sympathetic Coupling and Hemodynamic Response to Acute Mild Hypoxia in Female Rodents With Chronic Kidney Disease.Frontiers in physiology · 2021Article
- Sex differences in integrated neurocardiovascular control of blood pressure following acute intermittent hypercapnic hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Post-Exercise Hypotension and Reduced Cardiac Baroreflex after Half-Marathon Run: In Men, but Not in Women.International journal of environmental research and public health · 2020Article
- Sympathetically mediated increases in cardiac output, not restraint of peripheral vasodilation, contribute to blood pressure maintenance during hyperinsulinemia.American journal of physiology. Heart and circulatory physiology · 2020Article
- Noiseless Variable-Pressure Neck Chamber Device to Assess the Carotid Baroreflex Function.Frontiers in physiology · 2020Article
- Preserved ability to blunt sympathetically-mediated vasoconstriction in exercising skeletal muscle of young obese humans.Physiological reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
It is presently unknown whether there are sex differences in the magnitude of blood pressure (BP) responses to baroreceptor perturbation or if the relative contribution of cardiac output (CO) and total vascular conductance (TVC) to baroreflex-mediated changes in BP differs in young women and men. Since sympathetic vasoconstrictor tone is attenuated in women, we hypothesized that carotid baroreflex-mediated BP responses would be attenuated in women by virtue of a blunted vascular response (i.e., an attenuated TVC response). BP, heart rate (HR), and stroke volume were continuously recorded during the application of 5-s pulses of neck pressure (NP; carotid hypotension) and neck suction (NS; carotid hypertension) ranging from +40 to -80 Torr in women (n = 20, 21 ± 0.5 yr) and men (n = 20, 21 ± 0.4 yr). CO and TVC were calculated on a beat-to-beat basis. Women demonstrated greater depressor responses to NS (e.g., -60 Torr, -17 ± 1%baseline in women vs. -11 ± 1%baseline in men, P < 0.05), which were driven by augmented decreases in HR that, in turn, contributed to larger reductions in CO (-60 Torr, -15 ± 2%baseline in women vs. -6 ± 2%baseline in men, P < 0.05). In contrast, pressor responses to NP were similar in women and men (e.g., +40 Torr, +14 ± 2%baseline in women vs. +10 ± 1%baseline in men, P > 0.05), with TVC being the primary mediating factor in both groups. Our findings indicate that sex differences in the baroreflex control of BP are evident during carotid hypertension but not carotid hypotension. Furthermore, in contrast to our hypothesis, young women exhibited greater BP responses to carotid hypertension by virtue of a greater cardiac responsiveness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.