ArticleThe Plant cell2011
Tetrapyrrole synthesis of photosynthetic chromerids is likely homologous to the unusual pathway of apicomplexan parasites.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- The cryo-EM structure of Photosystem I from Chromera velia with a bound superoxide dismutase heterodimer.Nature communications · 2025Article
- Complex Endosymbioses I: From Primary to Complex Plastids, Serial Endosymbiotic Events.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Using Diatom and Apicomplexan Models to Study the Heme Pathway ofInternational journal of molecular sciences · 2021Article
- Enigmatic Evolutionary History of Porphobilinogen Deaminase in Eukaryotic Phototrophs.Biology · 2021Article
- Fatty Acid Biosynthesis in Chromerids.Biomolecules · 2020Article
- Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection.PLoS pathogens · 2020Article
- Characterization of the apicoplast-localized enzymeThe Journal of biological chemistry · 2020Article
- Vitamin and cofactor acquisition in apicomplexans: SynthesisThe Journal of biological chemistry · 2020Review
- There Is Treasure Everywhere: Reductive Plastid Evolution in Apicomplexa in Light of Their Close Relatives.Biomolecules · 2019Review
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- The antenna-like domain of the cyanobacterial ferrochelatase can bind chlorophyll and carotenoids in an energy-dissipative configuration.The Journal of biological chemistry · 2019Article
- Endosymbiotic Evolution of Algae, Secondary Heterotrophy and Parasitism.Biomolecules · 2019Review
- Subcellular Compartments Interplay for Carbon and Nitrogen Allocation in Chromera velia and Vitrella brassicaformis.Genome biology and evolution · 2019Article
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- Extensive gain and loss of photosystem I subunits in chromerid algae, photosynthetic relatives of apicomplexans.Scientific reports · 2017Article
- Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement.PloS one · 2016Article
- Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.
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