Evidence map›Paper›PMID 21963627›Full record

ArticleChemical communications (Cambridge, England)2011

Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.

Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, Lacey Harrington, Whittney N Burda, Lindsey N Shaw, Chuanhai Cao, Jianfeng Cai

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Antimicrobial AApeptides.Current topics in medicinal chemistry · 2017
    Review
  9. Article
  10. The development of antimicrobial γ-AApeptides.Future medicinal chemistry · 2016
    Review
  11. Article
  12. γ-AApeptides as a New Class of Peptidomimetics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016
    Article
  13. γ-AApeptides: Design, Structure, and Applications.Accounts of chemical research · 2016
    Article
  14. Article
  15. Article
  16. Article
  17. Design, synthesis and characterization of fMLF-mimicking AApeptides.Chembiochem : a European journal of chemical biology · 2014
    Article
  18. Short antimicrobial lipo-α/γ-AA hybrid peptides.Chembiochem : a European journal of chemical biology · 2014
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Youhong Niu *Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
Shruti Padhee *Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
Haifan WuDepartment of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
Ge BaiDepartment of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
Lacey HarringtonDepartment of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Whittney N BurdaDepartment of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Lindsey N ShawDepartment of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Chuanhai CaoDepartment of Molecular Pharmacology and Physiology, USF-Health Byrd Alzheimer's Institute, 4001 E. Fletcher Ave, Tampa, FL 33613, USA.
Jianfeng CaiDepartment of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.

Funding

Characterization of ??S in the stress & virulence responses of S. aureusR01AI080626 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2010 to 2013
$1.3M
NIAID NIH HHS 1R01AI080626-01A2NIAID NIH HHS R01 AI080626
6 · The paper itself

Abstract

We report the identification of a new class of antimicrobial peptidomimetics-γ-AApeptides with potent and broad-spectrum activity, including clinically-relevant strains that are unresponsive to most antibiotics. They are also not prone to select for drug-resistance.

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesBiomimetic MaterialsCandida albicansCell MembraneDrug Resistance, Multiple, BacterialEscherichia coliGram-Positive BacteriaKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Infective AgentsAntimicrobial Cationic Peptides

Identifiers

PMID21963627
PMCPMC3746764

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.