ArticleJournal of experimental botany2012
Glutaredoxin GRXS13 plays a key role in protection against photooxidative stress in Arabidopsis.
Article in Journal of experimental botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Identification of Key Differentially Expressed Genes inInternational journal of molecular sciences · 2025Pooled it
- Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis.Plant physiology · 2013Pooled it
- Emerging roles of glutaredoxins in plant metabolism.Journal of experimental botany · 2026Review
- Genome-wide identification and characterization of the glutaredoxin (GRX) family genes in wild soybean and their expression dynamics under salt and alkali conditions.Molecular biology reports · 2026Article
- Article
- A CC-Type Glutaredoxins GRX480 Functions in Cadmium Tolerance by Maintaining Redox Homeostasis in Arabidopsis.International journal of molecular sciences · 2024Article
- HScience (New York, N.Y.) · 2024Article
- Integration of shoot-derived polypeptide signals by root TGA transcription factors is essential for survival under fluctuating nitrogen environments.Nature communications · 2024Article
- Capsicum chinense Jacq.-derived glutaredoxin (CcGRXS12) alters redox status of the cells to confer resistance against pepper mild mottle virus (PMMoV-I).Plant cell reports · 2024Article
- Redox dynamics in seeds ofFrontiers in plant science · 2024Article
- Comparative Genomic Analysis of a NovelMicroorganisms · 2023Article
- Article
- CC-type glutaredoxin, MeGRXC3, associates with catalases and negatively regulates drought tolerance in cassava (Manihot esculenta Crantz).Plant biotechnology journal · 2022Article
- Positive selection and heat-response transcriptomes reveal adaptive features of the Brassicaceae desert model, Anastatica hierochuntica.The New phytologist · 2022Article
- Role of cassava CC-type glutaredoxin MeGRXC3 in regulating sensitivity to mannitol-induced osmotic stress dependent on its nuclear activity.BMC plant biology · 2022Article
- OsbZIP47 Is an Integrator for Meristem Regulators During Rice Plant Growth and Development.Frontiers in plant science · 2022Article
- miRNAs and lncRNAs in tomato: Roles in biotic and abiotic stress responses.Frontiers in plant science · 2022Review
- Oxidative stress response and programmed cell death guided by NAC013 modulate pithiness in radish taproots.The Plant journal : for cell and molecular biology · 2022Article
- Transcriptome sequencing and gene expression profiling ofBreeding science · 2021Article
- Host GRXC6 restricts Tomato yellow leaf curl virus infection by inhibiting the nuclear export of the V2 protein.PLoS pathogens · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutaredoxins (GRXs) belong to the antioxidant and signalling network involved in the cellular response to oxidative stress in bacterial and eukaryotic cells. In spite of the high number of GRX genes in plant genomes, the biological functions and physiological roles of most of them remain unknown. Here the functional characterization of the Arabidopsis GRXS13 gene (At1g03850), that codes for two CC-type GRX isoforms, is reported. The transcript variant coding for the GRXS13.2 isoform is predominantly expressed under basal conditions and is the isoform that is induced by photooxidative stress. Transgenic lines where the GRXS13 gene has been knocked down show increased basal levels of superoxide radicals and reduced plant growth. These lines also display reduced tolerance to methyl viologen (MeV) and high light (HL) treatments, both conditions of photooxidative stress characterized by increased production of superoxide ions. Consistently, lines overexpressing the GRXS13.2 variant show reduced MeV- and HL-induced damage. Alterations in GRXS13 expression also affect superoxide levels and the ascorbate/dehydroascorbate ratio after HL-induced stress. These results indicate that GRXS13 gene expression is critical for limiting basal and photooxidative stress-induced reactive oxygen species (ROS) production. Together, these results place GRXS13.2 as a member of the ROS-scavenging/antioxidant network that shows a particularly low functional redundancy in the Arabidopsis GRX family.
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