ArticleDevelopmental biology2011
Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Pri micropeptide functions as a cell-intrinsic timer controlling the transient phase of cell fate induction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025Review
- Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster.Scientific reports · 2024Article
- Mechanisms of NaFrontiers in physiology · 2022Review
- Isoform-specific roles of the Drosophila filamin-type protein Jitterbug (Jbug) during development.Genetics · 2021Article
- A Matrix Metalloproteinase Mediates Tracheal Development inInternational journal of molecular sciences · 2021Article
- Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila.Nature cell biology · 2021Article
- Dual oxidase enables insect gut symbiosis by mediating respiratory network formation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A hemipteran insect reveals new genetic mechanisms and evolutionary insights into tracheal system development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development.PLoS genetics · 2019Article
- Two-step regulation ofeLife · 2019Article
- Glial response to hypoxia in mutants of NPAS1/3 homolog Trachealess through Wg signaling to modulate synaptic bouton organization.PLoS genetics · 2019Article
- Crossveinless is a direct transcriptional target of Trachealess and Tango in Drosophila tracheal precursor cells.PloS one · 2019Article
- Comparative Expression Profiling of Wild TypeFrontiers in physiology · 2019Article
- Blimp-1 Mediates Tracheal Lumen Maturation inGenetics · 2018Article
- Development and Function of theGenetics · 2018Review
- Origin and diversification of wings: Insights from a neopteran insect.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration.Cell reports · 2015Article
- Multipotent versus differentiated cell fate selection in the developing Drosophila airways.eLife · 2015Article
- The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier.PLoS genetics · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila trachea is a branched tubular epithelia that transports oxygen and other gases. trachealess (trh), which encodes a bHLH-PAS transcription factor, is among the first genes to be expressed in the cells that will form the trachea. In the absence of trh, tracheal cells fail to invaginate to form tubes and remain on the embryo surface. Expression of many tracheal-specific genes depends on trh, but all of the known targets have relatively minor phenotypes compared to loss of trh, suggesting that there are additional targets. To identify uncharacterized transcriptional targets of Trh and to further understand the role of Trh in embryonic tracheal formation, we performed an in situ hybridization screen using a library of ~100 tracheal-expressed genes identified by the Berkeley Drosophila Genome Project (BDGP). Surprisingly, expression of every tracheal gene we tested was dependent on Trh, suggesting a major role for Trh in activation and maintenance of tracheal gene expression. A re-examination of the interdependence of the known early-expressed transcription factors, including trh, ventral veinless (vvl) and knirps/knirps-related (kni/knrl), suggests a new model for how gene expression is controlled in the trachea, with trh regulating expression of vvl and kni, but not vice versa. A pilot screen for the targets of Vvl and Kni/Knrl revealed that Vvl and Kni have only minor roles compared to Trh. Finally, genome-wide microarray experiments identified additional Trh targets and revealed that a variety of biological processes are affected by the loss of trh.
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Registered trials
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