Evidence map›Paper›PMID 21963197›Full record

ReviewTrends in genetics : TIG2011

Xenopus research: metamorphosed by genetics and genomics.

Richard M Harland, Robert M Grainger

Open access · greenAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 192 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026
    Review
  6. TheBiomolecules · 2025
    Review
  7. VersatileProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Review
  10. Systematic review:Frontiers in medicine · 2025
    Review
  11. Article
  12. Review
  13. Using Xenopus to discover new candidate genes involved in BOR and other congenital hearing loss syndromes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Biophysics reports · 2023
    Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Richard M HarlandDepartment of Molecular and Cell Biology, Center for Integrative Genomics, University of California Berkeley, CA 94720, USA.
Robert M Grainger
University of California, Berkeley · USUniversity of Virginia · US

Funding

Gene Expression in Amphibian DevlopementR01GM042341 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARLAND, RICHARD M · 1988 to 2016
$5.7M
AXIS FORMATION IN VERTEBRATE DEVELOPMENTR01GM049346 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARLAND, RICHARD M · 1993 to 2012
$3.7M
AMPHIBIAN MODEL FOR VERTEBRATE DEVELOPMENTAL GENETICSR01RR013221 · NCRR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GRAINGER, ROBERT M · 1998 to 2008
$2.8M
Pediatric Spectral Domain Optical Coherence TomographyR44EY019000 · NEI · BIOPTIGEN, INC. · PI BUCKLAND, ERIC L. · 2011 to 2014
$2.8M
Comparative Genetics and Genomics of XenopusR01GM086321 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARLAND, RICHARD M, ROKHSAR, DANIEL SOLEYMAN · 2009 to 2016
$2.5M
Genetic Control of Early Retinal DevelopmentR01EY017400 · NEI · UNIVERSITY OF VIRGINIA · PI GRAINGER, ROBERT M · 2006 to 2010
$1.8M
TISSUE INTERACTIONS IN EMBRYONIC LENS AND EYE FORMATIONR01EY006675 · NEI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GRAINGER, ROBERT M · 1986 to 2005
$1.7M
Genomic survey of cis-regulatory element function by high-throughput transgenesisR01EY018000 · NEI · UNIVERSITY OF VIRGINIA · PI GRAINGER, ROBERT M · 2009 to 2012
$1.3M
National Xenopus Resource CenterP40RR025867 · NCRR · MARINE BIOLOGICAL LABORATORY · PI GRAINGER, ROBERT M · 2010 to 2011
$1.3M
A genome assembly for Xenopus laevisR01HD065705 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARLAND, RICHARD M, ROKHSAR, DANIEL SOLEYMAN · 2010 to 2013
$1.2M
Development of a TILLING Resource for the Xenopus Research CommunityR21HD065713 · NICHD · UNIVERSITY OF VIRGINIA · PI GRAINGER, ROBERT M · 2010 to 2011
$443k
Genetic Analysis of Inner Ear Development in tropicalisR21DC010210 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARLAND, RICHARD M · 2009 to 2010
$395k
NCRR NIH HHS P40 RR025867NCRR NIH HHS R01 RR013221NCRR NIH HHS RR025867NEI NIH HHS EY017400NEI NIH HHS EY019000NEI NIH HHS R01 EY006675NEI NIH HHS R01 EY017400NEI NIH HHS R01 EY018000NEI NIH HHS R43 EY019000NEI NIH HHS R44 EY019000NICHD NIH HHS HD065705NICHD NIH HHS HD065713NICHD NIH HHS R01 HD065705NICHD NIH HHS R21 HD065713NIDCD NIH HHS DC010210NIDCD NIH HHS R21 DC010210NIGMS NIH HHS GM042341NIGMS NIH HHS GM049346NIGMS NIH HHS GM086321NIGMS NIH HHS R01 GM042341NIGMS NIH HHS R01 GM049346NIGMS NIH HHS R01 GM086321
6 · The paper itself

Abstract

Research using Xenopus takes advantage of large, abundant eggs and readily manipulated embryos in addition to conserved cellular, developmental and genomic organization with mammals. Research on Xenopus has defined key principles of gene regulation and signal transduction, embryonic induction, morphogenesis and patterning as well as cell cycle regulation. Genomic and genetic advances in this system, including the development of Xenopus tropicalis as a genetically tractable complement to the widely used Xenopus laevis, capitalize on the classical strengths and wealth of achievements. These attributes provide the tools to tackle the complex biological problems of the new century, including cellular reprogramming, organogenesis, regeneration, gene regulatory networks and protein interactions controlling growth and development, all of which provide insights into a multitude of human diseases and their potential treatments.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsGenomicsHumansMetamorphosis, BiologicalMutationXenopus

Identifiers

PMID21963197
PMCPMC3601910
OpenAlexW1976656951

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.