Evidence map›Paper›PMID 21963111›Full record

ReviewCurrent opinion in microbiology2011

A conserved regulatory role for antisense RNA in meiotic gene expression in yeast.

Huei-Mei Chen, Aaron M Neiman

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Huei-Mei ChenDepartment of Microbiology and Molecular Genetics, Stony Brook University, Stony Brook, NY 11794-5215, United States.
Aaron M Neiman
Stony Brook University · US

Funding

Wiring of Gene Expression in the Early Meiotic ProgramP01GM088297 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FUTCHER, BRUCE BRUCE · 2010 to 2014
$7.4M
NIGMS NIH HHS P01 GM088297
6 · The paper itself

Abstract

A significant fraction of the eukaryotic genome is transcribed into RNAs that do not encode proteins, termed non-coding RNA (ncRNA). One class of ncRNA that is of particular interest is antisense RNAs, which are complementary to protein coding transcripts (mRNAs). In this article, we summarize recent studies using different yeasts that reveal a conserved pattern in which meiotically expressed genes have antisense transcripts in vegetative cells. These antisense transcripts repress the basal transcription of the mRNA during vegetative growth and are diminished as cells enter meiosis. While the mechanism(s) by which these antisense RNAs interfere with production of sense transcripts is not yet understood, the effects appear to be independent of the canonical RNAi machinery.

Indexed as

Gene Expression Regulation, FungalMeiosisRNA, AntisenseSaccharomyces cerevisiaeRNA, Antisense

Identifiers

PMID21963111
PMCPMC3230709
OpenAlexW2049174301

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.