Trial reportAmerican journal of obstetrics and gynecology2012
Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer.
Trial report in American journal of obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06035068 (Sentinel Lymph Node Mapping and Detection With Indocyanine Green and Spy-Phi Handheld Camera Technology in Early-Stage Vulvar Cancer), which is not on this map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sentinel Lymph Node Mapping and Detection With Indocyanine Green and Spy-Phi Handheld Camera Technology in Early-Stage Vulvar Cancer (PILOT)
Who cites it
38 citing papers in PubMed, 97 citations in OpenAlex.
- Fluorescence cholangiography during laparoscopic cholecystectomy: a feasibility study on early biliary tract delineation.Surgical endoscopy · 2013Trial
- Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers.BJOG : an international journal of obstetrics and gynaecology · 2013Trial
- Update on near infrared imaging technology: indocyanine green and near infrared technology in the treatment of gynecologic cancers.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024Review
- Sentinel Lymph Node Evaluation in Early-Stage Vulvar Cancer.Current treatment options in oncology · 2024Review
- Single Camera-Based Dual-Channel Near-Infrared Fluorescence Imaging system.Sensors (Basel, Switzerland) · 2022Article
- Performance of Indocyanine Green Compared to 99mTc-Nanocolloids for Sentinel Lymph Node Detection in Early Vulvar Cancer.Current oncology (Toronto, Ont.) · 2022Article
- Management of Early-Stage Vulvar Cancer.Cancers · 2022Review
- Development of Intraoperative Near-Infrared Fluorescence Imaging System Using a Dual-CMOS Single Camera.Sensors (Basel, Switzerland) · 2022Article
- Detection of the sentinel lymph node with hybrid tracer (ICG-[EJNMMI research · 2021Article
- Exploratory Study of the Clinical Value of Near-Infrared Sentinel Lymph Node Mapping With Indocyanine Green in Vulvar Cancer Patients.Frontiers in oncology · 2021Article
- Lymphoscintigraphy and sentinel lymph node biopsy in vulvar carcinoma: update from a European expert panel.European journal of nuclear medicine and molecular imaging · 2020Review
- IGCS Intraoperative Technology Taskforce. Update on near infrared imaging technology: beyond white light and the naked eye, indocyanine green and near infrared technology in the treatment of gynecologic cancers.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2020Review
- Current and novel mapping substances in gynecologic cancer care.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2020Review
- Nanotechnology in Oral Cavity Carcinoma: Recent Trends and Treatment Opportunities.Nanomaterials (Basel, Switzerland) · 2019Review
- Stereoscopic Near-Infrared Fluorescence Imaging: A Proof of Concept Toward Real-Time Depth Perception in Surgical Robotics.Frontiers in robotics and AI · 2019Article
- Review
- Use of methylene blue and near-infrared fluorescence in thyroid and parathyroid surgery.Langenbeck's archives of surgery · 2018Article
- A Tumor-Activatable Theranostic Nanomedicine Platform for NIR Fluorescence-Guided Surgery and Combinatorial Phototherapy.Theranostics · 2018Article
- Sentinel lymph node mapping in gynecological oncology.Oncology letters · 2017Article
- Role of ICG-European journal of nuclear medicine and molecular imaging · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesNear-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. STUDY
designNine vulvar cancer patients underwent the standard sentinel lymph node procedure using (99m)technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750, or 1000 μM of indocyanine green adsorbed to human serum albumin.
resultsNear-infrared fluorescence sentinel lymph node mapping was successful in all patients. A total of 14 sentinel lymph nodes (average, 1.6; range, 1-4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 near-infrared fluorescent (100%).
conclusionThis study demonstrates feasibility and accuracy of sentinel lymph node mapping using indocyanine green adsorbed to human serum albumin. Considering safety, cost, and pharmacy preferences, an indocyanine green adsorbed to human serum albumin concentration of 500 μM appears optimal for sentinel lymph node mapping in vulvar cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.