ArticleImmunity2011
Evolutionarily conserved features contribute to αβ T cell receptor specificity.
Article in Immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 66 citations in OpenAlex.
- Developmental features and unique characteristics of peptide-specific PLZFNature communications · 2025Article
- Article
- Evolutionary trade-offs constraining the MHC gene expansion: beyond simple TCR depletion model.Frontiers in immunology · 2023Article
- MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction.Frontiers in immunology · 2022Review
- Natural killer cell responses to emerging viruses of zoonotic origin.Current opinion in virology · 2020Review
- MHC Restriction: Where Are We Now?Viral immunology · 2020Article
- Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolutionary Underpinnings of Innate-Like T Cell Interactions with Cancer.Immunological investigations · 2019Review
- The expanding role of systems immunology in decoding the T cell receptor repertoire.Current opinion in systems biology · 2018Article
- Development of T cell lines sensitive to antigen stimulation.Journal of immunological methods · 2018Article
- Profiling of the TCRβ repertoire in non-model species using high-throughput sequencing.Scientific reports · 2018Article
- Understanding the drivers of MHC restriction of T cell receptors.Nature reviews. Immunology · 2018Review
- T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.European journal of immunology · 2018Article
- Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.The Journal of experimental medicine · 2017Article
- A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck.Scientific reports · 2017Article
- Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Evolution of innate-like T cells and their selection by MHC class I-like molecules.Immunogenetics · 2016Review
- Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.The Journal of clinical investigation · 2016Article
- Revealing the TCR bias for MHC molecules.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.Nature immunology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
αβ T cell receptors (TCRs) bind specifically to foreign antigens presented by major histocompatibility complex proteins (MHC) or MHC-like molecules. Accumulating evidence indicates that the germline-encoded TCR segments have features that promote binding to MHC and MHC-like molecules, suggesting coevolution between TCR and MHC molecules. Here, we assess directly the evolutionary conservation of αβ TCR specificity for MHC. Sequence comparisons showed that some Vβs from distantly related jawed vertebrates share amino acids in their complementarity determining region 2 (CDR2). Chimeric TCRs containing amphibian, bony fish, or cartilaginous fish Vβs can recognize antigens presented by mouse MHC class II and CD1d (an MHC-like protein), and this recognition is dependent upon the shared CDR2 amino acids. These results indicate that features of the TCR that control specificity for MHC and MHC-like molecules were selected early in evolution and maintained between species that last shared a common ancestor more than 400 million years ago.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.