Trial reportTransactions of the Royal Society of Tropical Medicine and Hygiene2011
Efficacy of malaria prevention during pregnancy in an area of low and unstable transmission: an individually-randomised placebo-controlled trial using intermittent preventive treatment and insecticide-treated nets in the Kabale Highlands, southwestern Uganda.
Trial report in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Systematic review of statistical methods for safety data in malaria chemoprevention in pregnancy trials.Malaria journal · 2020Pooled it
- Pooled it
- Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment.The Cochrane database of systematic reviews · 2014Pooled it
- Neonatal mortality risk associated with preterm birth in East Africa, adjusted by weight for gestational age: individual participant level meta-analysis.PLoS medicine · 2012Pooled it
- A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Malawi.Malaria journal · 2022Trial
- A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso.Malaria journal · 2020Trial
- Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission.Malaria journal · 2015Trial
- The burden of malaria-attributable maternal anaemia and the impact of preventive treatment across sub-Saharan Africa.Nature health · 2026Article
- Factors associated with intermittent preventive treatment (IPTp-SP) use for malaria during pregnancy in Somalia: a multilevel analysis of the 2020 demographic and health survey.Malaria journal · 2025Article
- Household predictors of malaria episode in northern Uganda: its implication for future malaria control.BMC public health · 2025Article
- Interventions for malaria prevention in pregnancy; factors influencing uptake and their effect on pregnancy outcomes among post-natal women in a tertiary facility in the Volta Region of Ghana.SAGE open medicine · 2023Article
- Uptake of intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) in Uganda: a national survey.Malaria journal · 2022Article
- Malaria chemoprevention and drug resistance: a review of the literature and policy implications.Malaria journal · 2022Review
- The impact of malaria during pregnancy on low birth weight in East-Africa: a topical review.Malaria journal · 2021Review
- Community-based delivery of intermittent preventive treatment of malaria in pregnancy in Burkina Faso: a qualitative study.Malaria journal · 2021Article
- Malaria knowledge and experiences with community health workers among recently pregnant women in Malawi.Malaria journal · 2020Article
- Article
- Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21BMJ (Clinical research ed.) · 2017Article
- Malaria during Pregnancy.Cold Spring Harbor perspectives in medicine · 2017Review
- Utilization of health facilities and maternal malaria prevention strategies by pregnant women in Kajiado County, a highland pastoral area of Kenya with low malaria transmission.MalariaWorld journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Intermittent preventive treatment of malaria during pregnancy (IPTp) and insecticide-treated nets (ITN) are recommended malaria interventions during pregnancy; however, there is limited information on their efficacy in areas of low malaria transmission in sub-Saharan Africa. An individually-randomised placebo-controlled trial involving 5775 women of all parities examined the effect of IPTp, ITNs alone, or ITNs used in combination with IPTp on maternal anaemia and low birth weight (LBW) in a highland area of southwestern Uganda. The overall prevalence of malaria infection, maternal anaemia and LBW was 15.0%, 14.7% and 6.5%, respectively. Maternal and fetal outcomes were generally remarkably similar across all intervention groups (P>0.05 for all outcomes examined). A marginal difference in maternal haemoglobin was observed in the dual intervention group (12.57g/dl) compared with the IPTp and ITN alone groups (12.40g/dl and 12.44g/dl, respectively; P=0.04), but this was too slight to be of clinical importance. In conclusion, none of the preventive strategies was found to be superior to the others, and no substantial additional benefit to providing both IPTp and ITNs during routine antenatal services was observed. With ITNs offering a number of advantages over IPTp, yet showing comparable efficacy, we discuss why ITNs could be an appropriate preventive strategy for malaria control during pregnancy in areas of low and unstable transmission.
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