ArticleBMC infectious diseases2011
Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections, rt269L and rt269I.World journal of gastroenterology · 2023Article
- Prediction for HBsAg seroconversion in children with chronic hepatitis B.BMC infectious diseases · 2021Article
- Association of hepatitis B genotypes with clinical profile of patients with chronic hepatitis B.International journal of molecular epidemiology and genetics · 2020Article
- Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.World journal of gastroenterology · 2018Review
- Identification and comparative analysis of hepatitis B virus genotype D/E recombinants in Africa.Virus genes · 2017Article
- Influence of Treg cells and HBV genotype on sustained response and drug resistance in the treatment with nucleoside drugs.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Molecular characterisation of hepatitis B virus in HIV-1 subtype C infected patients in Botswana.BMC infectious diseases · 2015Article
- A novel method for detection of HBVcccDNA in hepatocytes using rolling circle amplification combined with in situ PCR.BMC infectious diseases · 2014Article
- The correlation between T helper type 17 cells and clinical characters in Chinese paediatric patients with chronic hepatitis B.Clinical and experimental immunology · 2013Article
- Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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11 authors.
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Abstract
backgroundThe association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown.
methodsFour hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. The stage of fibrosis and degree of inflammatory activity were evaluated by the Metavir score system.
resultsAmong 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent (73.7% and 21.1%). Comparing with HBV/B2 infected patients, no significant difference was observed in the incidence rate and mutant patterns of lamivudine- or adefovir-resistant mutations in HBV/C2 infected patients (P > 0.05). Importantly, we found that the degree of hepatic inflammation degree, fibrosis stage and ALT level were significantly higher in HBV/C2-infected HBeAg positive patients than it was in HBV/B2-infected ones.
conclusionsThe pediatric patients with HBV/C2 infection might be more susceptible to develop severe liver pathogenesis.
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