ArticleBMC gastroenterology2011
Two cases of monomicrobial intraabdominal abscesses due to KPC--3 Klebsiella pneumoniae ST258 clone.
Article in BMC gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Thrombocytopenia inFrontiers in cellular and infection microbiology · 2024Article
- Clinical characteristics and outcome of patients with enterococcal liver abscess.Scientific reports · 2021Article
- Emerging high-risk ST101 and ST307 carbapenem-resistant Klebsiella pneumoniae clones from bloodstream infections in Southern Italy.Annals of clinical microbiology and antimicrobials · 2020Article
- Calculated parenteral initial treatment of bacterial infections: Intra-abdominal infections.GMS infectious diseases · 2020Article
- Co-existence of virulence factors and antibiotic resistance in new Klebsiella pneumoniae clones emerging in south of Italy.BMC infectious diseases · 2019Article
- The microbiota of the bilio-pancreatic system: a cohort, STROBE-compliant study.Infection and drug resistance · 2019Article
- Bactibilia in diseases of the biliary tract and pancreatic gland in patients older than 80 years: a STROBE-retrospective cohort study in a teaching hospital in Italy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Ertapenem non-susceptibility and independent predictors of the carbapenemase production among the Enterobacteriaceae isolates causing intra-abdominal infections in the Asia-Pacific region: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART).Infection and drug resistance · 2018Article
- Shifting trends in bacteriology and antimicrobial resistance among gastrointestinal fistula patients in China: an eight-year review in a tertiary-care hospital.BMC infectious diseases · 2017Article
- The role of Enterococcus spp. and multidrug-resistant bacteria causing pyogenic liver abscesses.BMC infectious diseases · 2017Article
- What Healthcare Workers Should Know about Environmental Bacterial Contamination in the Intensive Care Unit.BioMed research international · 2017Review
- Multi-drug-resistant Klebsiella pneumoniae pancreatitis: a new challenge in a serious surgical infection.Surgical infections · 2015Article
- Management of Intra-abdominal Infections due to Carbapenemase-Producing Organisms.Current infectious disease reports · 2014Article
- Pancreatitis in tigecycline Phase 3 and 4 clinical studies.The Journal of antimicrobial chemotherapy · 2014Article
- Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance.Antimicrobial agents and chemotherapy · 2014Article
- Surgical pathology and the diagnosis of invasive visceral yeast infection: two case reports and literature review.World journal of emergency surgery : WJES · 2013Article
- KPC - 3 Klebsiella pneumoniae ST258 clone infection in postoperative abdominal surgery patients in an intensive care setting: analysis of a case series of 30 patients.BMC anesthesiology · 2013Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnowledge of the etiology of pyogenic liver and pancreatic abscesses is an important factor in determining the success of combined surgical and antibiotic treatment. Literature shows geographical variations in the prevalence and distribution of causative organisms, and the spread of Klebsiella pneumoniae carbapenemase-producing bacteria is an emerging cause of abdominal infections. CASE PRESENTATION: We herein describe two cases of intra-abdominal abscesses due to monomicrobial infection by Klebsiella pneumoniae Sequence Type 258 producing K. pneumoniae carbapenemase 3 (KPC-Kp). In case 1, a 50-year-old HIV-negative Italian woman with chronic pancreatitis showed infection of a pancreatic pseudocystic lesion caused by KPC-Kp. In case 2, a 64-year-old HIV-negative Italian woman with pancreatic neoplasm and liver metastases developed a liver abscess due to KPC after surgery. Both women were admitted to our hospital but to different surgical units. The clonal relationship between the two isolates was investigated by pulsed-field gel electrophoresis (PFGE). In case 2, the patient was already colonized at admission and inter-hospital transmission of the pathogen was presumed. A long-term combination regimen of colistin with tigecycline and percutaneous drainage resulted in full recovery and clearance of the multidrug-resistant (MDR) pathogen.
conclusionsTimely microbiological diagnosis, the combined use of new and old antibiotics and radiological intervention appeared to be valuable in managing these serious conditions. The emergence and dissemination of MDR organisms is posing an increasing challenge for physicians to develop new therapeutic strategies and control and prevention frameworks.
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