ReviewAnnual review of pharmacology and toxicology2012
Addiction circuitry in the human brain.
Review in Annual review of pharmacology and toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 271 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Charleston ARC Clinical Project 4 Cortical rTMS as a Tool to Change Craving and Brain Reactivity to Alcohol Cues
Theta Burst TMS as a Tool to Change Smoking Behavior
The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children
Who cites it
271 citing papers in PubMed, 8 syntheses or guidelines pooled it, 569 citations in OpenAlex.
- Functional magnetic response imaging predictors of alcohol use disorder treatment outcome: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Pooled it
- Effect of addiction on brain glucose metabolism assessed by PET/CT molecular imaging: a systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Is Deep Brain Stimulation an Effective Treatment for Psychostimulant Dependency? A Preclinical and Clinical Systematic Review.Neurochemical research · 2023Pooled it
- Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2019Pooled it
- What Is the Evidence for "Food Addiction?" A Systematic Review.Nutrients · 2018Pooled it
- Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.The international journal of neuropsychopharmacology · 2016Pooled it
- Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.Translational psychiatry · 2016Pooled it
- Treating tobacco use disorder in pregnant women in medication-assisted treatment for an opioid use disorder: a systematic review.Journal of substance abuse treatment · 2015Pooled it
- Reduced executive and reward connectivity is associated with smoking cessation response to repetitive transcranial magnetic stimulation: A double-blind, randomized, sham-controlled trial.Brain imaging and behavior · 2024Trial
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Buprenorphine and Methadone as Opioid Maintenance Treatments for Heroin-Addicted Patients Induce Oxidative Stress in Blood.Oxidative medicine and cellular longevity · 2019Trial
- Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex reduces resting-state insula activity and modulates functional connectivity of the orbitofrontal cortex in cigarette smokers.Drug and alcohol dependence · 2017Trial
- Dopamine D2/3- and μ-opioid receptor antagonists reduce cue-induced responding and reward impulsivity in humans.Translational psychiatry · 2016Trial
- The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Administration of an extrasynaptic δ-subunit GABAJournal of psychopharmacology (Oxford, England) · 2026Article
- The Invisible Abuser: Attachment, Victimization, and Perpetrator Perception in Repeat Abuse.Violence against women · 2026Article
- Divergent disinhibition profiles linked to externalizing psychopathology.Journal of psychopathology and clinical science · 2026Article
- Altered Functional Connectivity in the Reward Circuit in Betel Quid-Dependent Chewers.Addiction biology · 2026Article
- Emotional Eating and Its Associations with the Prevalence of Depression and Anxiety Symptoms in University Students: A Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2026Article
- Fentanyl Induces Behavioral Sensitization and Decreases Class IIa HDAC Expression-Activity in Brain as Measured by [Brain sciences · 2026Article
211 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
A major challenge in understanding substance-use disorders lies in uncovering why some individuals become addicted when exposed to drugs, whereas others do not. Although genetic, developmental, and environmental factors are recognized as major contributors to a person's risk of becoming addicted, the neurobiological processes that underlie this vulnerability are still poorly understood. Imaging studies suggest that individual variations in key dopamine-modulated brain circuits, including circuits involved in reward, memory, executive function, and motivation, contribute to some of the differences in addiction vulnerability. A better understanding of the main circuits affected by chronic drug use and the influence of social stressors, developmental trajectories, and genetic background on these circuits is bound to lead to a better understanding of addiction and to more effective strategies for the prevention and treatment of substance-use disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.