ArticleAnalytical chemistry2011
Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed, 246 citations in OpenAlex.
- Oxygels: Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen.Advanced healthcare materials · 2026Article
- Article
- Systematic tissue oxygen variation shows the modulation of murine skin radiation toxicity at ultra-high dose rates.Physics in medicine and biology · 2026Article
- Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy.Experimental physiology · 2026Article
- Differential effects of phenylephrine on brain versus skeletal muscle microvascular perfusion: an in vivo laboratory study using translational rodent models.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Timescale of FLASH Sparing Effect Determined by Varying Temporal Split of Dose Delivery in Mice.International journal of radiation oncology, biology, physics · 2026Article
- Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction.Experimental physiology · 2026Article
- Selective Pharmacological Blockade of GPR39 Markedly Reduces No Reflow and Infarct Volumes in a Rat Model of Acute Myocardial Infarction.bioRxiv : the preprint server for biology · 2026Article
- The Role of Nitric Oxide in Regulating Microvascular Oxygen Pressure During Diaphragm Contraction in Rats.Advances in experimental medicine and biology · 2026Article
- Imaging lymphatic function and inflammation response through hypoxia via endogenous biomarker.Journal of biomedical optics · 2026Article
- In vitro oxygen concentration alters reactive oxygen species yields with minor plasmid DNA damage change at ultra-high-dose rate.The British journal of radiology · 2026Article
- Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intermediate tissue oxygen level is required to observe murine FLASH skin sparing.bioRxiv : the preprint server for biology · 2025Article
- Rescuing Ischemic Brain Injury by Rewiring Mitochondrial Electron Flow.bioRxiv : the preprint server for biology · 2025Article
- Dynamic oxygen assessment techniques enable determination of anesthesia's impact on tissue.Scientific reports · 2025Article
- Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.bioRxiv : the preprint server for biology · 2025Article
- Multimodal retinal imaging by visible light optical coherence tomography and phosphorescence lifetime ophthalmoscopy in the mouse eye.Neurophotonics · 2025Article
- Oxygen Consumption In Vivo by Ultra-High Dose Rate Electron Irradiation Depends Upon Baseline Tissue Oxygenation.International journal of radiation oncology, biology, physics · 2025Article
- Anesthesia is a potent determinant of ultra-high dose rate sparing in the murine total abdominal irradiation model.Frontiers in oncology · 2025Article
- Article
60 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We report the synthesis, calibration, and examples of application of two new phosphorescent probes, Oxyphor R4 and Oxyphor G4, optimized specifically for in vivo oxygen imaging by phosphorescence quenching. These "protected" dendritic probes can operate in either albumin-rich (blood plasma) or albumin-free (interstitial space) environments at all physiological oxygen concentrations, from normoxic to deep hypoxic conditions. Oxyphors R4 and G4 are derived from phosphorescent Pd-meso-tetra-(3,5-dicarboxyphenyl)-porphyrin (PdP) or Pd-meso-tetra-(3,5-dicarboxyphenyl)-tetrabenzoporphyrin (PdTBP), respectively, and possess features common for protected dendritic probes, i.e., hydrophobic dendritic encapsulation of phosphorescent metalloporphyrins and hydrophilic PEGylated periphery. The new Oxyphors are highly soluble in aqueous environments and do not permeate biological membranes. The probes were calibrated under physiological conditions (pH 6.4-7.8) and temperatures (22-38 °C), showing high stability, reproducibility of signals, and lack of interactions with biological solutes. Oxyphor G4 was used to dynamically image intravascular and interstitial oxygenation in murine tumors in vivo. The physiological relevance of the measurements was demonstrated by dynamically recording changes in tissue oxygenation during application of anesthesia (isofluorane). These experiments revealed that changes in isofluorane concentration significantly affect tissue oxygenation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.