ArticleFrontiers in physiology2011
The genetic component of the forced diving bradycardia response in mammals.
Article in Frontiers in physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The risk of decompression illness in breath-hold divers: a systematic review.Diving and hyperbaric medicine · 2023Pooled it
- The Mammalian Diving Response: Inroads to Its Neural Control.Frontiers in neuroscience · 2020Review
- Conditioned Variation in Heart Rate During Static Breath-Holds in the Bottlenose Dolphin (Frontiers in physiology · 2020Article
- Spleen Size and Function in Sherpa Living High, Sherpa Living Low and Nepalese Lowlanders.Frontiers in physiology · 2020Article
- Training rats to voluntarily dive underwater: investigations of the mammalian diving response.Journal of visualized experiments : JoVE · 2014Article
- The mammalian diving response: an enigmatic reflex to preserve life?Physiology (Bethesda, Md.) · 2013Review
- Gastric mucosal damage in water immersion stress: mechanism and prevention with GHRP-6.World journal of gastroenterology · 2012Article
- Activation of brainstem neurons by underwater diving in the rat.Frontiers in physiology · 2012Article
- The physiological consequences of breath-hold diving in marine mammals: the Scholander legacy.Frontiers in physiology · 2012Article
- Animal models for investigating the central control of the Mammalian diving response.Frontiers in physiology · 2012Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We contrasted the forced diving bradycardia between two genetically similar (inbred) rat strains (Fischer and Buffalo), compared to that of outbred rats (Wistar). The animals were habituated to forced diving for 4 weeks. Each animal was then tested during one 40 s dive on each of 3 days. The heart rate (f(H)) was measured before, during, and after each dive. Fischer and Buffalo exhibited marked difference in dive bradycardia (Fischer: 120.9 ± 14.0 beats min(-1) vs. Buffalo: 92.8 ± 12.8 beats min(-1), P < 0.05). Outbred rats showed an intermediate response (103.0 ± 30.9 beats min(-1)) but their between-animal variability in mean dive f(H) and pre-diving resting f(H) were higher than the inbred strains (P < 0.05), which showed no difference (P > 0.05). The decreased variability in f(H) in inbred rats as compared with the outbred group indicates that reduced genetic variability minimizes variability of the diving bradycardia between individuals. Heritability within strains was assessed by the repeatability (R) index and was 0.93 ± 0.05 for the outbred, 0.84 ± 0.16 for Buffalo, and 0.80 ± 0.12 for Fischer rats for f(H) during diving. Our results suggest that a portion of the mammalian diving bradycardia may be a heritable trait.
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