ArticleLearning & memory (Cold Spring Harbor, N.Y.)2011
Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Effects of sodium benzoate on cognitive function in neuropsychiatric disorders: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Brain Activity of Benzoate, a D-Amino Acid Oxidase Inhibitor, in Patients With Mild Cognitive Impairment in a Randomized, Double-Blind, Placebo Controlled Clinical Trial.The international journal of neuropsychopharmacology · 2021Trial
- Intracellular regulation of a serotonin-gated ion channel links receptor trafficking to memory.iScience · 2026Article
- Inefficacy of a novel osmotic associative learning assay in C. elegans.BMC research notes · 2026Article
- INS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans.PLoS genetics · 2026Article
- Compressed sensing-based approach identifies modular neural circuitry driving learned pathogen avoidance.eLife · 2026Article
- INS-17, an insulin-receptor ligand, confers specificity in adult IIS-regulated phenotypes inbioRxiv : the preprint server for biology · 2025Article
- Extracellular vesicles aid in the transfer of long-term associative memory betweenResearch square · 2025Article
- Extracellular vesicles aid in the transfer of long-term associative memory betweenbioRxiv : the preprint server for biology · 2025Article
- Experimental modeling of Alzheimer's disease: Translational lessons from cross-taxon analyses.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Resolving transitions between distinct phases of memory consolidation at high resolution iniScience · 2024Article
- Inheritance of associative memories and acquired cellular changes in C. elegans.Nature communications · 2023Article
- Article
- A dynamical model ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Uncovering novel regulators of memory using C. elegans genetic and genomic analysis.Biochemical Society transactions · 2023Review
- Anesthesia Resistant Memories in Drosophila, a Working Perspective.International journal of molecular sciences · 2022Review
- Association of Two Opposing Responses Results in the Emergence of a Novel Conditioned Response.Frontiers in behavioral neuroscience · 2022Article
- Fear conditioning in invertebrates.Frontiers in behavioral neuroscience · 2022Review
- Article
- Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans.BMC biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nematode Caenorhabditis elegans (C. elegans) adult hermaphrodite has 302 invariant neurons and is suited for cellular and molecular studies on complex behaviors including learning and memory. Here, we have developed protocols for classical conditioning of worms with 1-propanol, as a conditioned stimulus (CS), and hydrochloride (HCl) (pH 4.0), as an unconditioned stimulus (US). Before the conditioning, worms were attracted to 1-propanol and avoided HCl in chemotaxis assay. In contrast, after massed or spaced training, worms were either not attracted at all to or repelled from 1-propanol on the assay plate. The memory after the spaced training was retained for 24 h, while the memory after the massed training was no longer observable within 3 h. Worms pretreated with transcription and translation inhibitors failed to form the memory by the spaced training, whereas the memory after the massed training was not significantly affected by the inhibitors and was sensitive to cold-shock anesthesia. Therefore, the memories after the spaced and massed trainings can be classified as long-term memory (LTM) and short-term/middle-term memory (STM/MTM), respectively. Consistently, like other organisms including Aplysia, Drosophila, and mice, C. elegans mutants defective in nmr-1 encoding an NMDA receptor subunit failed to form both LTM and STM/MTM, while mutations in crh-1 encoding the CREB transcription factor affected only the LTM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.