ArticleChest2012
Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.
Article in Chest, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.BMC pulmonary medicine · 2014Trial
- Racial differences in CT phenotypes in COPD.COPD · 2013Trial
- The construct validity of real-world digital mobility outcomes in people with COPD.ERJ open research · 2026Article
- The Association of Race and Ethnicity with Six-Minute Walk Distance: The Multi-Ethnic Study of Atherosclerosis.Ethnicity & disease · 2026Article
- Topologic Parametric Response Mapping Identifies Tissue Subtypes Associated with Emphysema Progression.Academic radiology · 2024Article
- Determinants of Six-Minute Walk Distance in Idiopathic Pulmonary Fibrosis and Idiopathic Pleuroparenchymal Fibroelastosis.Biomedicines · 2022Article
- Chronotropic index during 6-minute walk and acute respiratory events in COPDGene.Respiratory medicine · 2022Article
- Respiratory Oscillometry in Chronic Obstructive Pulmonary Disease: Association with Functional Capacity as Evaluated by Adl Glittre Test and Hand Grip Strength Test.International journal of chronic obstructive pulmonary disease · 2022Article
- Pulmonary Emphysema Regional Distribution and Extent Assessed by Chest Computed Tomography Is Associated With Pulmonary Function Impairment in Patients With COPD.Frontiers in medicine · 2021Article
- Physiologic Insights from the COPD Genetic Epidemiology Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Review
- Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.Respiratory research · 2018Observational
- Article
- Respiratory constraints during activities in daily life and the impact on health status in patients with early-stage COPD: a cross-sectional study.NPJ primary care respiratory medicine · 2016Article
- Vulnerability to Renal, Heat and Respiratory Hospitalizations During Extreme Heat Among U.S. Elderly.Climatic change · 2016Article
- A Robust Emphysema Severity Measure Based on Disease Subtypes.Academic radiology · 2016Article
- Long-term effects of gastrectomy in patients with spirometry-defined COPD and patients at risk of COPD: a case-control study.International journal of chronic obstructive pulmonary disease · 2015Article
- Association of chronic cough and pulmonary function with 6-minute walk test performance in HIV infection.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Activity restriction in mild COPD: a challenging clinical problem.International journal of chronic obstructive pulmonary disease · 2014Review
- Review
- Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers.American journal of respiratory and critical care medicine · 2013Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundExercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV(1). We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) in the COPDGene cohort.
methodsCOPDGene recruits non-Hispanic Caucasian and African American current and ex-smokers. Phenotyping measures include postbronchodilator FEV(1) % predicted and inspiratory and expiratory CT lung scans. We defined % emphysema as the percentage of lung voxels < -950 Hounsfield units on the inspiratory scan and % gas trapping as the percentage of lung voxels < -856 Hounsfield units on the expiratory scan.
resultsData of the first 2,500 participants of the COPDGene cohort were analyzed. Participant age was 61 ± 9 years; 51% were men; 76% were non-Hispanic Caucasians, and 24% were African Americans. Fifty-six percent had spirometrically defined COPD, with 9.3%, 23.4%, 15.0%, and 8.3% in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I to IV, respectively. Higher % emphysema and % gas trapping predicted lower 6MWD (P < .001). However, in a given spirometric group, after adjustment for age, sex, race, and BMI, neither % emphysema nor % gas trapping, or their interactions with FEV(1) % predicted, remained a significant 6MWD predictor. In a given spirometric group, only 16% to 27% of the variance in 6MWD could be explained by age, male sex, Caucasian race, and lower BMI as significant predictors of higher 6MWD.
conclusionsIn this large cohort of smokers in a given spirometric stage, phenotypic characteristics were only modestly predictive of 6MWD. CT scan measures of emphysema and gas trapping were not predictive of 6MWD after adjustment for other phenotypic characteristics.
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