ArticleCardiovascular research2012
High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects.
Article in Cardiovascular research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Plasma phospholipid saturated fatty acids and heart failure risk in the Physicians' Health Study.Clinical nutrition (Edinburgh, Scotland) · 2013Trial
- Plasma phospholipid trans fatty acids and risk of heart failure.The American journal of clinical nutrition · 2013Trial
- A high-fat diet nutritional intervention reprograms cardiac metabolism and improves systolic function in a pig model of heart failure with reduced ejection fraction.Basic research in cardiology · 2026Article
- Dietary unsaturated fatty acids distinctly associate with the early age sleep-wake cycle and gut integrity in aged fruit flies, Drosophila melanogaster.Biogerontology · 2026Article
- Association of dietary preferences with cardiovascular disease: a Mendelian randomization study.Atherosclerosis plus · 2025Article
- Sex differences in the regulation of spatially distinct cardiac mitochondrial subpopulations.Molecular and cellular biochemistry · 2016Article
- An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus.Journal of diabetes research · 2016Review
- Excess Linoleic Acid Increases Collagen I/III Ratio and "Stiffens" the Heart Muscle Following High Fat Diets.The Journal of biological chemistry · 2015Article
- Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome.Journal of molecular and cellular cardiology · 2015Article
- Effect of high-fat diet on rat myometrium during pregnancy-isolated myometrial mitochondria are not affected.Pflugers Archiv : European journal of physiology · 2015Article
- Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2015Article
- Cardiac mitochondrial proteome dynamics with heavy water reveals stable rate of mitochondrial protein synthesis in heart failure despite decline in mitochondrial oxidative capacity.Journal of molecular and cellular cardiology · 2014Article
- Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies.American journal of physiology. Heart and circulatory physiology · 2014Review
- Effect of a high-protein diet on development of heart failure in response to pressure overload.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2014Article
- Creatine, L-carnitine, and ω3 polyunsaturated fatty acid supplementation from healthy to diseased skeletal muscle.BioMed research international · 2014Article
- Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure.Cardiovascular drugs and therapy · 2013Article
- Dietary saturated fat and docosahexaenoic acid differentially effect cardiac mitochondrial phospholipid fatty acyl composition and Ca(2+) uptake, without altering permeability transition or left ventricular function.Physiological reports · 2013Article
- Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis.Cardiovascular diabetology · 2013Article
- Enhanced resistance to permeability transition in interfibrillar cardiac mitochondria in dogs: effects of aging and long-term aldosterone infusion.American journal of physiology. Heart and circulatory physiology · 2013Article
- Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival.American journal of physiology. Heart and circulatory physiology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
aimsThe impact of a high-fat diet on the failing heart is unclear, and the differences between polyunsaturated fatty acids (PUFA) and saturated fat have not been assessed. Here, we compared a standard low-fat diet to high-fat diets enriched with either saturated fat (palmitate and stearate) or PUFA (linoleic and α-linolenic acids) in hamsters with genetic cardiomyopathy. METHODS AND
resultsMale δ-sarcoglycan null Bio TO2 hamsters were fed a standard low-fat diet (12% energy from fat), or high-fat diets (45% fat) comprised of either saturated fat or PUFA. The median survival was increased by the high saturated fat diet (P< 0.01; 278 days with standard diet and 361 days with high saturated fat)), but not with high PUFA (260 days) (n = 30-35/group). Body mass was modestly elevated (∼10%) in both high fat groups. Subgroups evaluated after 24 weeks had similar left ventricular chamber size, function, and mass. Mitochondrial oxidative enzyme activity and the yield of interfibrillar mitochondria (IFM) were decreased to a similar extent in all TO2 groups compared with normal F1B hamsters. Ca(2+)-induced mitochondrial permeability transition pore opening was enhanced in IFM in all TO2 groups compared with F1B hamsters, but to a significantly greater extent in those fed the high PUFA diet compared with the standard or high saturated fat diet.
conclusionThese results show that a high intake of saturated fat improves survival in heart failure compared with a high PUFA diet or low-fat diet, despite persistent mitochondrial defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.