Ascorbic acid: what do we really no?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

1. Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports.BMC pulmonary medicine · 2024
   Pooled it
2. Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis.Frontiers in cardiovascular medicine · 2022
   Pooled it
3. Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis.Nutrients · 2019
   Pooled it
4. Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress.The Journal of physiology · 2012
   Trial
5. Reversible severe pulmonary hypertension related to scurvy in children.BMC cardiovascular disorders · 2024
   Article
6. Reversible Pulmonary Hypertension Secondary to Scurvy in a Patient with a Psychiatric Disorder: a Case Report and Literature Review.European journal of case reports in internal medicine · 2020
   Article
7. A Very Uncommon Case of Pulmonary Hypertension.CASE (Philadelphia, Pa.) · 2018
   Article
8. Local infusion of ascorbate augments NO-dependent cutaneous vasodilatation during intense exercise in the heat.The Journal of physiology · 2015
   Article
9. NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease.American journal of physiology. Renal physiology · 2014
   Article
10. Cardiac arrest and pulmonary hypertension in scurvy: a case report.Pulmonary circulation
    Article
11. Body temperature regulation in diabetes.Temperature (Austin, Tex.)
    Review

Corrections and comments

• Comment on
  Nitric oxide and neurally mediated regulation of skin blood flow during local heating.2001
• Comment on
  Skin blood flow and nitric oxide during body heating in type 2 diabetes mellitus.2009
• Comment on
  Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease.2011

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as