ArticleAmerican journal of respiratory cell and molecular biology2012
Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness.
Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Pneumocystis jirovecii is a potential pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly.Communications biology · 2025Article
- Role of the FungusInternational journal of molecular sciences · 2024Article
- Article
- Refractory flare-up of severe bronchial asthma controlled with mepolizumab due to Pneumocystis pneumonia: a case report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Review
- Survey of the Transcription Factor Responses of Mouse Lung Alveolar Macrophages toPathogens (Basel, Switzerland) · 2021Article
- Bronchoscopy in severe childhood asthma: Irresponsible or irreplaceable?Pediatric pulmonology · 2020Review
- Leucine rich repeat LGI family member 3: Integrative analyses reveal its prognostic association with non-small cell lung cancer.Oncology letters · 2019Article
- Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection.Scientific reports · 2019Article
- Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-InducedFrontiers in microbiology · 2019Article
- Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways.PloS one · 2019Article
- Epigenetics of Mucus Hypersecretion in Chronic Respiratory Diseases.American journal of respiratory cell and molecular biology · 2018Review
- New advances in understanding the host immune response to Pneumocystis.Current opinion in microbiology · 2017Review
- Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework.Particle and fibre toxicology · 2017Article
- Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Diagnosis of the primary infection by pneumocystis in autopsy specimens from two infants using lung impression smears (touch preps).Medical mycology case reports · 2014Article
- Fungal colonization with Pneumocystis correlates to increasing chloride channel accessory 1 (hCLCA1) suggesting a pathway for up-regulation of airway mucus responses, in infant lungs.Results in immunology · 2014Article
- Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia.Infection and immunity · 2013Article
- Near-universal prevalence of Pneumocystis and associated increase in mucus in the lungs of infants with sudden unexpected death.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
It is widely held that exposure to pathogens such as fungi can be an agent of comorbidity, such as exacerbation of asthma or chronic obstructive pulmonary disease. Although many studies have examined allergic responses to fungi and their effects on pulmonary function, the possible pathologic implications of the early innate responses to fungal pathogens have not been explored. We examined early responses to the atypical fungus Pneumocystis in two common strains of mice in terms of overall immunological response and related pathology, such as cell damage and airway hyperresponsiveness (AHR). We found a strong strain-specific response in BALB/c mice that included recruitment of neutrophils, NK, NKT, and CD4 T cells. This response was accompanied by elevated indicators of lung damage (bronchoalveolar lavage fluid albumin and LDH) and profound AHR. This early response was absent in C57BL/6 mice, although both strains exhibited a later response associated with the clearance of Pneumocystis. We found that this AHR could not be attributed exclusively to the presence of recruited neutrophils, NKT, NK, or CD4 cells or to the actions of IFN-γ or IL-4. However, in the absence of STAT6 signaling, AHR and inflammatory cell recruitment were virtually absent. Gene expression analysis indicated that this early response included activation of several transcription factors that could be involved in pulmonary remodeling. These results show that exposure to a fungus such as Pneumocystis can elicit pulmonary responses that may contribute to morbidity, even without prior sensitization, in the context of certain genetic backgrounds.
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Registered trials
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