ArticleChembiochem : a European journal of chemical biology2011
Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose.
Article in Chembiochem : a European journal of chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-DerivedMarine drugs · 2024Article
- Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins.ACS omega · 2023Article
- Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R.ACS chemical biology · 2018Article
- Selvamicin, an atypical antifungal polyene from two alternative genomic contexts.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Tailoring pathway modularity in the biosynthesis of erythromycin analogs heterologously engineered in E. coli.Science advances · 2015Article
- Arginine-rhamnosylation as new strategy to activate translation elongation factor P.Nature chemical biology · 2015Article
- PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells.Oncotarget · 2014Article
- Molecular insight into substrate recognition and catalysis of Baeyer-Villiger monooxygenase MtmOIV, the key frame-modifying enzyme in the biosynthesis of anticancer agent mithramycin.ACS chemical biology · 2013Article
- Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.Angewandte Chemie (International ed. in English) · 2012Article
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Authors and funding
4 authors.
Funding
Abstract
Mix'n'match: Enzymatic total synthesis of TDP-D-olivose was achieved, starting from TDP-4-keto-6-deoxy-D-glucose, by combining three pathway enzymes with one cofactor-regenerating enzyme. The results also revealed that MtmC is a bifunctional enzyme that can perform a 4-ketoreduction necessary for D-olivose biosynthesis besides the previously found C-methyltransfer for D-mycarose biosynthesis.
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