ArticleProceedings of the National Academy of Sciences of the United States of America2011
Behavior-specific changes in transcriptional modules lead to distinct and predictable neurogenomic states.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
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Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of honey bee neurogenomic response links Deformed wing virus type A to precocious behavioral maturation.Scientific reports · 2020Pooled it
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- Comparative efficacy and mechanistic insights of non-invasive neuromodulation and motor rehabilitation on functional reorganization of the supplementary motor area in subacute stroke: a narrative review.Frontiers in physiology · 2026Review
- Transcriptional responses in feeder time-trained foragers suggest diverse interactions between the circadian clock and mushroom bodies in honey bees.Scientific reports · 2025Article
- The Neuropeptide Neuroparsin-A Regulates the Establishment of Dominance Hierarchy in Bumblebees.International journal of molecular sciences · 2025Article
- Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees.Nature communications · 2025Article
- Integrating computer vision and molecular neurobiology to bridge the gap between behavior and the brain.Current opinion in insect science · 2024Review
- Molecular underpinnings underlying behaviors changes in the brain of juvenile common carp (Cyrinus carpio) in response to warming.Journal of advanced research · 2024Article
- Quantitative estimates of the regulatory influence of long non-coding RNAs on global gene expression variation using TCGA breast cancer transcriptomic data.PLoS computational biology · 2024Article
- Effects of microRNA-305 knockdown on brain gene expression associated with division of labor in honey bee colonies (Apis mellifera).The Journal of experimental biology · 2024Article
- Gut microbiota contribute to variations in honey bee foraging intensity.The ISME journal · 2024Article
- Predicting the impact of sequence motifs on gene regulation using single-cell data.Genome biology · 2023Article
- Single-cell dissection of aggression in honeybee colonies.Nature ecology & evolution · 2023Article
- Brain Gene Expression of Foraging Behavior and Social Environment in Ceratina calcarata.Genome biology and evolution · 2023Article
- Behavioral genetics and genomics: Mendel's peas, mice, and bees.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Social divergence: molecular pathways underlying castes and longevity in a facultatively eusocial small carpenter bee.Proceedings. Biological sciences · 2022Article
- Time-course RNASeq of Camponotus floridanus forager and nurse ant brains indicate links between plasticity in the biological clock and behavioral division of labor.BMC genomics · 2022Article
- Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected byFrontiers in cellular and infection microbiology · 2022Article
- Searching beyond the streetlight: Neonicotinoid exposure alters the neurogenomic state of worker honey bees.Ecology and evolution · 2021Article
27 more citing papers are in PubMed but not listed here.
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Abstract
Using brain transcriptomic profiles from 853 individual honey bees exhibiting 48 distinct behavioral phenotypes in naturalistic contexts, we report that behavior-specific neurogenomic states can be inferred from the coordinated action of transcription factors (TFs) and their predicted target genes. Unsupervised hierarchical clustering of these transcriptomic profiles showed three clusters that correspond to three ecologically important behavioral categories: aggression, maturation, and foraging. To explore the genetic influences potentially regulating these behavior-specific neurogenomic states, we reconstructed a brain transcriptional regulatory network (TRN) model. This brain TRN quantitatively predicts with high accuracy gene expression changes of more than 2,000 genes involved in behavior, even for behavioral phenotypes on which it was not trained, suggesting that there is a core set of TFs that regulates behavior-specific gene expression in the bee brain, and other TFs more specific to particular categories. TFs playing key roles in the TRN include well-known regulators of neural and behavioral plasticity, e.g., Creb, as well as TFs better known in other biological contexts, e.g., NF-κB (immunity). Our results reveal three insights concerning the relationship between genes and behavior. First, distinct behaviors are subserved by distinct neurogenomic states in the brain. Second, the neurogenomic states underlying different behaviors rely upon both shared and distinct transcriptional modules. Third, despite the complexity of the brain, simple linear relationships between TFs and their putative target genes are a surprisingly prominent feature of the networks underlying behavior.
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