Evidence map›Paper›PMID 21960414›Full record

ArticleInternational journal of cancer2012

Ovarian cancer risk factors by histologic subtypes in the NIH-AARP Diet and Health Study.

Hannah P Yang, Britton Trabert, Megan A Murphy, Mark E Sherman, Joshua N Sampson, Louise A Brinton, Patricia Hartge, Albert Hollenbeck, Yikyung Park, Nicolas Wentzensen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 9 pooled it
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 9 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
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  8. Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
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  15. Associations between Parity, History of Breastfeeding, and T-cell Profile of Ovarian Tumors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  16. Global, regional, and national burden of ovarian cancer among young women during 1990-2019.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hannah P YangDepartment of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. yanghan@mail.nih.gov
Britton Trabert
Megan A Murphy
Mark E Sherman
Joshua N Sampson
Louise A Brinton
Patricia Hartge
Albert Hollenbeck
Yikyung Park
Nicolas Wentzensen
National Cancer Institute · USNational Institutes of Health · USAARP · US

Funding

Prospective Studies of Diet and Cancer in the AARP CohortZIACP010196 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SINHA, RASHMI · 2009 to 2025
$21.0M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Intramural NIH HHS ZIA CP010196NCI NIH HHS 5 T32 CA09001-35NCI NIH HHS T32 CA009001
6 · The paper itself

Abstract

Data suggest that risk factors for ovarian carcinoma vary by histologic type, but findings are inconsistent. We prospectively evaluated risk factors by histological subtypes of incident ovarian cancer (n = 849) in a cohort of 169,391 women in the NIH-AARP Diet and Health Study. We constructed Cox models of individual exposures by comparing case subtypes to the entire non-case group and assessed p-heterogeneity in case-case comparisons using serous as the reference category. Substantial risk differences between histologic subtypes were observed for menopausal hormone therapy (MHT) use, oral contraceptive (OC) use, parity and body mass index (p-heterogeneity = 0.01, 0.03, 0.05, 0.03, respectively). MHT users were at increased risk for all histologic subtypes except for mucinous carcinomas, where risk was reduced (relative risk (RR) = 0.37; 95% confidence interval (CI): 0.18, 0.80). OC users were only at significantly decreased risk for serous cancers (RR = 0.69; 95% CI: 0.55, 0.85). Although parity was inversely associated with risk of all subtypes, the RRs ranged from 0.28 (clear cell) to 0.83 (serous). Obesity was a significant risk factor only for endometrioid cancers (RR = 1.64; 95% CI: 1.00, 2.70). Our findings support a link between etiological factors and histological heterogeneity in ovarian carcinoma.

Indexed as

AgedBody Mass IndexContraceptives, Oral, HormonalEstrogen Replacement TherapyFemaleHumansIncidenceMiddle AgedOvarian NeoplasmsProportional Hazards ModelsProspective StudiesRisk FactorsUnited StatesContraceptives, Oral, Hormonal

Identifiers

PMID21960414
PMCPMC3505848
OpenAlexW2159575833

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.