ArticleJournal of perinatology : official journal of the California Perinatal Association2012
Hypoproteinemia on the first day of life and adverse outcome in very preterm infants admitted to the neonatal intensive care unit.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Brain injury in twin anemia-polycythemia sequence: prevalence, severity and long-term neurodevelopmental outcome.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Risk factors for prolonged ICU stay following congenital oesophageal Atresia surgery: a retrospective study.BMC pediatrics · 2025Article
- Blood volume reduction due to rapid plasma loss after birth in preterm piglets.Pediatric research · 2024Article
- Low albumin levels are independently associated with neonatal acute kidney injury: a report from AWAKEN Study Group.Pediatric nephrology (Berlin, Germany) · 2022Article
- Efficacy comparison of high-frequency oscillatory ventilation with continuous nasal positive airway pressure in neonatal respiratory distress syndrome treatment.American journal of translational research · 2021Article
- Neonatal Refeeding Syndrome and Clinical Outcome in Extremely Low-Birth-Weight Babies: Secondary Cohort Analysis From the ProVIDe Trial.JPEN. Journal of parenteral and enteral nutrition · 2021Article
- Relationship Between Serum Albumin Levels and Infections in Newborn Late Preterm Infants.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Total plasma protein in very preterm babies: prognostic value and comparison with illness severity scores.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to investigate the relationship between day-1 hypoproteinemia and severe adverse outcome (SAO) in very preterm infants admitted to the neonatal intensive care unit (NICU). STUDY
designRetrospective study of all patients born from 24 to 31 weeks gestation and cared for in our NICU over an 8-year period. Infants were excluded if the serum protein value on the first day of life was not available.
resultA total of 913 patients were included. In all, 14.6% presented with SAO (death or severe neurological injury on cranial ultrasound). Hypoproteinemia (total protein level <40 g l(-1)) on day 1 of life occurred in 19.5 % of all patients. The rate of SAO was 33.7% in patients with hypoproteinemia and 9.9% in those with normoproteinemia (P<0.0001). Logistic and multiple regression analysis confirmed that the association hypoproteinemia-SAO remained significant after adjustment for the other major predictors of outcome present at baseline (odds ratio 3.4; 95% confidence interval 2.1-5.4; P<0.0001).
conclusionHypoproteinemia was highly associated with SAO in this cohort of critically ill preterm infants. We are unable to explain the link between hypoproteinemia and adverse outcome in our population. This investigation serves as a hypothesis-generating report of a large preterm infants sample, and suggests the need to assess the predictive accuracy for adverse outcome of hypoproteinemia in future prospective studies.
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