ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- MIGGRI: A multi-instance graph neural network model for inferring gene regulatory networks for Drosophila from spatial expression images.PLoS computational biology · 2023Article
- The Roles of the LIM Domain Proteins inFrontiers in cardiovascular medicine · 2021Review
- Quantitative analyses of EGFR localization and trafficking dynamics in the follicular epithelium.Development (Cambridge, England) · 2020Article
- Predicting gene regulatory interactions based on spatial gene expression data and deep learning.PLoS computational biology · 2019Article
- Article
- Simple Expression Domains Are Regulated by Discrete CRMs DuringG3 (Bethesda, Md.) · 2017Article
- FlyExpress 7: An Integrated Discovery Platform To Study Coexpressed Genes UsingG3 (Bethesda, Md.) · 2017Article
- Representation of anatomy in online atlases and databases: a survey and collection of patterns for interface design.BMC developmental biology · 2016Article
- myFX: a turn-key software for laboratory desktops to analyze spatial patterns of gene expression in Drosophila embryos.Bioinformatics (Oxford, England) · 2014Article
- Automated annotation of developmental stages of Drosophila embryos in images containing spatial patterns of expression.Bioinformatics (Oxford, England) · 2014Article
- Chorion patterning: a window into gene regulation and Drosophila species' relatedness.Molecular biology and evolution · 2014Article
- Article
- Exploring spatial patterns of gene expression from fruit fly embryogenesis on the iPhone.Bioinformatics (Oxford, England) · 2012Article
- FlyExpress: visual mining of spatiotemporal patterns for genes and publications in Drosophila embryogenesis.Bioinformatics (Oxford, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOverlaps in spatial patterns of gene expression are frequently an initial clue to genetic interactions during embryonic development. However, manual inspection of images requires considerable time and resources impeding the discovery of important interactions because tens of thousands of images exist. The FlyExpress discovery platform was developed to facilitate data-driven comparative analysis of expression pattern images from Drosophila embryos.
resultsAn image-based search of the BDGP and Fly-FISH datasets conducted in FlyExpress yields fewer but more precise results than text-based searching when the specific goal is to find genes with overlapping expression patterns. We also provide an example of a FlyExpress contribution to scientific discovery: an analysis of gene expression patterns for multigene family members revealed that spatial divergence is far more frequent than temporal divergence, especially after the maternal to zygotic transition. This discovery provides a new clue to molecular mechanisms whereby duplicated genes acquire novel functions.
conclusionsThe application of FlyExpress to understanding the process by which new genes acquire novel functions is just one of a myriad of ways in which it can contribute to our understanding of developmental and evolutionary biology. This resource has many other potential applications, limited only by the investigator's imagination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.