Evidence map›Paper›PMID 21959625›Full record

ReviewMedical science monitor : international medical journal of experimental and clinical research2011

Reciprocal regulation of cellular nitric oxide formation by nitric oxide synthase and nitrite reductases.

George B Stefano, Richard M Kream

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Behaviorally-Mediated Entrainment of Whole-Body Metabolic Processes: Conservation and Evolutionary Development of Mitochondrial Respiratory Complexes.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  5. Review
  6. Review
  7. Review
  8. Microbiome: A Potential Component in the Origin of Mental Disorders.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Review
  9. Nitric Oxide and Related Aspects Underlying Angina.The open cardiovascular medicine journal · 2017
    Review
  10. Review
  11. Evaluation of exhaled nitric oxide in acute paraquat poisoning: a pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2014
    Article
  12. Review
  13. Article
  14. Convergent dysregulation of frontal cortical cognitive and reward systems in eating disorders.Medical science monitor : international medical journal of experimental and clinical research · 2013
    Review
  15. Review
  16. Review
  17. NOS3 Polymorphisms and Chronic Kidney Disease.Jornal brasileiro de nefrologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

George B StefanoNeuroscience Research Institute, State University of New York - College at Old Westbury, Old Westbury, NY 11568-0210, USA. gstefano@sunynri.org
Richard M Kream
SUNY Old Westbury · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our mini-review focuses on dual regulation of cellular nitric oxide (NO) signaling pathways by traditionally characterized enzymatic formation from L-arginine via the actions of NO synthases (NOS) and by enzymatic reduction of available cellular nitrite pools by a diverse class of cytosolic and mitochondrial nitrite reductases. Nitrite is a major metabolic product of NO and is found in all cell and tissue types that utilize NO signaling processes. Xanthine oxidoreductase (XOR) has been previously characterized as a housekeeping enzyme responsible for cellular uric acid formation via enzymatic conversion of hypoxanthine and xanthine. It has become apparent that XOR possesses multi-functional enzymatic activities outside the realm of xanthine metabolism and a small but significant literature also established a compelling functional association between administered sodium nitrite, XOR activation, and pharmacologically characterized NO transductive effects in positive cardiovascular function enhanced pulmonary perfusion, and protection against ischemia/reperfusion injury and hypoxic damage and oxidative stress. Similar positive vascular and cellular effects were observed to be functionally associated with mitochondrial aldehyde dehydrogenase and cytochrome c/cytochrome c oxidase. The profound implications of a reciprocal regulatory mechanism responsible for cytosolic and mitochondrial NO production are discussed below.

Indexed as

Aldehyde DehydrogenaseArginineCytosolElectron Transport Complex IVMitochondriaModels, BiologicalMyocardial Perfusion ImagingNitric OxideNitric Oxide SynthaseNitrite ReductasesSignal TransductionXanthine DehydrogenaseAldehyde DehydrogenaseArginineElectron Transport Complex IVNitric OxideNitric Oxide SynthaseNitrite ReductasesXanthine Dehydrogenase

Identifiers

PMID21959625
PMCPMC3539480
OpenAlexW2001737452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.