ArticleFertility and sterility2011
Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes.
Article in Fertility and sterility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis.Journal of assisted reproduction and genetics · 2016Pooled it
- Null genotypes of GSTM1 and GSTT1 and endometriosis risk: a meta-analysis of 25 case-control studies.PloS one · 2014Pooled it
- Dioxin exposure associated with fecundability and infertility in mothers and daughters of Seveso, Italy.Human reproduction (Oxford, England) · 2021Article
- The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China.Clinical, cosmetic and investigational dermatology · 2021Article
- Relationship betweenInternational journal of reproductive biomedicine · 2018Article
- Involvement of 17β-hydroxysteroid dehydrogenase type gene 1 937 A>G polymorphism in infertility in Polish Caucasian women with endometriosis.Journal of assisted reproduction and genetics · 2017Article
- Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2017Article
- Common variation of theGenomics data · 2017Article
- Association between glutathione S-transferase M1/T1 gene polymorphisms and susceptibility to endometriosis: A systematic review and meta-analysis.Experimental and therapeutic medicine · 2016Article
- CYP2C19 polymorphism increases the risk of endometriosis.Journal of assisted reproduction and genetics · 2015Article
- CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.Experimental & molecular medicine · 2014Article
- ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure.Disease markers · 2013Article
- Insights into Assessing the Genetics of Endometriosis.Current obstetrics and gynecology reports · 2012Article
- The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis.Human reproduction updateReview
- Sex hormone-related polymorphisms in endometriosis and migraine: A narrative review.Women's health (London, England)Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk.
designGenetic polymorphism analysis.
settingPopulation-based case-control study conducted in Group Health Cooperative enrollees in western Washington. PATIENT(S): Women with newly diagnosed, surgically confirmed endometriosis between 1996 and 2001 (n = 256) and age- and reference year-matched female control subjects without a history of endometriosis (n = 567). INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): We evaluated the relationship between common genetic variation and endometriosis risk, using gene-based tests and single-variant analysis of genetic polymorphisms in ESR1, ESR2, PGR, CYP17A1, CYP19A1, HSD17B1, HSD17B2, CYP1A1, CYP1A2, COMT, and GSTM1. RESULT(S): The most consistent gene-based association with endometriosis risk was for CYP19A1. We did not find evidence for consistent significant associations between previously reported candidate SNPs in sex hormone-related genes and endometriosis risk. CONCLUSION(S): In summary, we report increased endometriosis risk with CYP19A1 gene-based tests; replication of the association between endometriosis and this gene or gene region is necessary in a larger study population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.