ArticleBiochimica et biophysica acta2012
Empirical derivation of the reference region for computing diagnostic sensitive ¹⁸fluorodeoxyglucose ratios in Alzheimer's disease based on the ADNI sample.
Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A Systematic Review of Longitudinal Studies Which Measure Alzheimer's Disease Biomarkers.Journal of Alzheimer's disease : JAD · 2017Pooled it
- Pilot study of repeated blood-brain barrier disruption in patients with mild Alzheimer's disease with an implantable ultrasound device.Alzheimer's research & therapy · 2022Trial
- Circulating palmitoleic acid is associated with cerebral glucose metabolism in healthy middle-aged individuals: results from the Progression of Early Subclinical Atherosclerosis prospective cohort study.The American journal of clinical nutrition · 2026Observational
- Contribution of local amyloid-β and tau burden to hypometabolism in autosomal-dominant Alzheimer's disease.Brain communications · 2026Article
- The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer's disease.Brain communications · 2025Article
- Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum.European journal of nuclear medicine and molecular imaging · 2022Article
- Brain alterations in the early Alzheimer's continuum with amyloid-β, tau, glial and neurodegeneration CSF markers.Brain communications · 2022Article
- Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort.NeuroImage. Clinical · 2021Article
- Accuracy and generalization capability of an automatic method for the detection of typical brain hypometabolism in prodromal Alzheimer disease.European journal of nuclear medicine and molecular imaging · 2019Article
- Longitudinal tau accumulation and atrophy in aging and alzheimer disease.Annals of neurology · 2019Article
- Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity.Nature communications · 2017Article
- 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population.NeuroImage · 2014Article
- The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Review
- Application of the National Institute on Aging-Alzheimer's Association AD criteria to ADNI.Neurology · 2013Article
- Article
- Neuroimaging statistical approaches for determining neural correlates of Alzheimer's disease via positron emission tomography imaging.Wiley interdisciplinary reviews. Computational statisticsArticle
- Support vector machine-based classification of neuroimages in Alzheimer's disease: direct comparison of FDG-PET, rCBF-SPECT and MRI data acquired from the same individuals.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Careful selection of the reference region for non-quantitative positron emission tomography (PET) analyses is critically important for Region of Interest (ROI) data analyses. We introduce an empirical method of deriving the most suitable reference region for computing neurodegeneration sensitive (18)fluorodeoxyglucose (FDG) PET ratios based on the dataset collected by the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. Candidate reference regions are selected based on a heat map of the difference in coefficients of variation (COVs) of FDG ratios over time for each of the Automatic Anatomical Labeling (AAL) atlas regions normalized by all other AAL regions. Visual inspection of the heat map suggests that the portion of the cerebellum and vermis superior to the horizontal fissure is the most sensitive reference region. Analyses of FDG ratio data show increases in significance on the order of ten-fold when using the superior portion of the cerebellum as compared with the traditionally used full cerebellum. The approach to reference region selection in this paper can be generalized to other radiopharmaceuticals and radioligands as well as to other disorders where brain changes over time are hypothesized and longitudinal data is available. Based on the empirical evidence presented in this study, we demonstrate the usefulness of the COV heat map method and conclude that intensity normalization based on the superior portion of the cerebellum may be most sensitive to measuring change when performing longitudinal analyses of FDG-PET ratios as well as group comparisons in Alzheimer's disease. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.
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