ArticleBrain, behavior, and immunity2012
The biobehavioral and neuroimmune impact of low-dose ionizing radiation.
Article in Brain, behavior, and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Long-Term, Sex-Specific Effects of GCRsim and Gamma Irradiation on the Brains, Hearts, and Kidneys of Mice with Alzheimer's Disease Mutations.International journal of molecular sciences · 2024Article
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- Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats.Journal of radiation research · 2022Article
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- Ionizing radiation, cerebrovascular disease, and consequent dementia: A review and proposed framework relevant to space radiation exposure.Frontiers in physiology · 2022Review
- Quantitative Analysis of Effects of a SingleInternational journal of environmental research and public health · 2020Article
- Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model.Metabolites · 2020Article
- Handling stress impairs learning through a mechanism involving caspase-1 activation and adenosine signaling.Brain, behavior, and immunity · 2019Article
- Fatigue following radiation therapy in nasopharyngeal cancer survivors: A dosimetric analysis incorporating patient report and observer rating.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2019Article
- Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats.Neurobiology of aging · 2019Article
- Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities.Nutrition & metabolism · 2018Article
- Neuroimmunology of Behavioral Comorbidities Associated With Cancer and Cancer Treatments.Frontiers in immunology · 2018Review
- Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition.Metabolism: clinical and experimental · 2017Article
- A Mouse Model of Fatigue Induced by Peripheral Irradiation.Journal of visualized experiments : JoVE · 2017Article
- Influence of age, irradiation and humanization on NSG mouse phenotypes.Biology open · 2015Article
- Chronic low-dose γ-irradiation of Drosophila melanogaster larvae induces gene expression changes and enhances locomotive behavior.Journal of radiation research · 2015Article
- Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation.Journal of cancer research and clinical oncology · 2015Review
- Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit.Life (Basel, Switzerland) · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
In the clinical setting, repeated exposures (10-30) to low-doses of ionizing radiation (≤200 cGy), as seen in radiotherapy for cancer, causes fatigue. Almost nothing is known, however, about the fatigue inducing effects of a single exposure to environmental low-dose ionizing radiation that might occur during high-altitude commercial air flight, a nuclear reactor accident or a solar particle event (SPE). To investigate the short-term impact of low-dose ionizing radiation on mouse biobehaviors and neuroimmunity, male CD-1 mice were whole body irradiated with 50 cGy or 200 cGy of gamma or proton radiation. Gamma radiation was found to reduce spontaneous locomotor activity by 35% and 36%, respectively, 6 h post irradiation. In contrast, the motivated behavior of social exploration was un-impacted by gamma radiation. Examination of pro-inflammatory cytokine gene transcripts in the brain demonstrated that gamma radiation increased hippocampal TNF-α expression as early as 4 h post-irradiation. This was coupled to subsequent increases in IL-1RA (8 and 12 h post irradiation) in the cortex and hippocampus and reductions in activity-regulated cytoskeleton-associated protein (Arc) (24 h post irradiation) in the cortex. Finally, restraint stress was a significant modulator of the neuroimmune response to radiation blocking the ability of 200 cGy gamma radiation from impairing locomotor activity and altering the brain-based inflammatory response to irradiation. Taken together, these findings indicate that low-dose ionizing radiation rapidly activates the neuroimmune system potentially causing early onset fatigue-like symptoms in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.