Evidence map›Paper›PMID 21958146›Full record

ReviewFuture microbiology2011

Human papillomavirus and cervical cancer: biomarkers for improved prevention efforts.

Vikrant V Sahasrabuddhe, Patricia Luhn, Nicolas Wentzensen

Registry-linked trialAbstract readReview
In one paragraph

Review in Future microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02247999 (Improving Cervical Cancer Prevention Among HIV-Infected Women Using Novel HPV Based Biomarker Assays), which is not on this map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02247999 completednot on this mapstarted 2012, after this paper: background citation

Improving Cervical Cancer Prevention Among HIV-Infected Women Using Novel HPV Based Biomarker Assays

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2012 to 2020Enrolled1,000ConditionsCervical Cancer, HIV/AIDS, HPV, Cervical Intraepithelial Neoplasia
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. The Role of Human Papillomavirus E6 Oncoprotein as a Biomarker in Anal Cancer Screening in Persons Living with HIV.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  7. Article
  8. Thymopoietin-The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  9. Article
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  16. Epigenetic approaches for cervical neoplasia screening (Review).Experimental and therapeutic medicine · 2021
    Review
  17. Article
  18. Review
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Vikrant V SahasrabuddheDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd EPS 5024, Rockville MD 20852, USA.
Patricia Luhn
Nicolas Wentzensen
National Cancer Institute · USNational Institutes of Health · US

Funding

Human papillomavirus (HPV) infection and cervical and anal cancersZIACP010124 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI WENTZENSEN, NICOLAS · 2009 to 2025
$17.3M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010124NCI NIH HHS Y99 CA999999
6 · The paper itself

Abstract

While organized screening programs in industrialized countries have significantly reduced cervical cancer incidence, cytology-based screening has several limitations. Equivocal or mildly abnormal Pap tests require costly retesting or diagnostic work-up by colposcopy and biopsy. In low-resource countries, it has been difficult to establish and sustain cytology-based programs. Advances in understanding human papillomavirus biology and the natural history of human papillomavirus-related precancers and cancers have led to the discovery of a range of novel biomarkers in the past decade. In this article, we will discuss the potential role of new biomarkers for primary screening, triage and diagnosis in high-resource countries and their promise for prevention efforts in resource constrained settings.

Indexed as

AlphapapillomavirusBiomarkers, TumorEarly Detection of CancerFemaleGenes, ViralHumansMass ScreeningMolecular Diagnostic TechniquesPapillomavirus InfectionsUterine Cervical NeoplasmsBiomarkers, Tumor

Identifiers

PMID21958146
PMCPMC3809085
OpenAlexW2119332284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.