Evidence map›Paper›PMID 21958071›Full record

ArticleBMC genomics2011

Detection of growth-related QTL in turbot (Scophthalmus maximus).

Enrique Sánchez-Molano, Alex Cerna, Miguel A Toro, Carmen Bouza, Miguel Hermida, Belén G Pardo, Santiago Cabaleiro, Jesús Fernández, Paulino Martínez

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Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

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31citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  11. Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes): a fish adapted to demersal life.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Enrique Sánchez-MolanoDepartamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain.
Alex Cerna
Miguel A Toro
Carmen Bouza
Miguel Hermida
Belén G Pardo
Santiago Cabaleiro
Jesús Fernández
Paulino Martínez

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe turbot (Scophthalmus maximus) is a highly appreciated European aquaculture species. Growth related traits constitute the main goal of the ongoing genetic breeding programs of this species. The recent construction of a consensus linkage map in this species has allowed the selection of a panel of 100 homogeneously distributed markers covering the 26 linkage groups (LG) suitable for QTL search. In this study we addressed the detection of QTL with effect on body weight, length and Fulton's condition factor.

resultsEight families from two genetic breeding programs comprising 814 individuals were used to search for growth related QTL using the panel of microsatellites available for QTL screening. Two different approaches, maximum likelihood and regression interval mapping, were used in order to search for QTL. Up to eleven significant QTL were detected with both methods in at least one family: four for weight on LGs 5, 14, 15 and 16; five for length on LGs 5, 6, 12, 14 and 15; and two for Fulton's condition factor on LGs 3 and 16. In these LGs an association analysis was performed to ascertain the microsatellite marker with the highest apparent effect on the trait, in order to test the possibility of using them for marker assisted selection.

conclusionsThe use of regression interval mapping and maximum likelihood methods for QTL detection provided consistent results in many cases, although the high variation observed for traits mean among families made it difficult to evaluate QTL effects. Finer mapping of detected QTL, looking for tightly linked markers to the causative mutation, and comparative genomics are suggested to deepen in the analysis of QTL in turbot so they can be applied in marker assisted selection programs.

Indexed as

Chromosome MappingQuantitative Trait LociAnimalsBody WeightBreedingFlatfishesGenetic LinkageLikelihood FunctionsMicrosatellite RepeatsPhenotypeRegression Analysis

Identifiers

PMID21958071
PMCPMC3195100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.