ReviewJournal of cardiac surgery2012
Matrix metalloproteinases and descending aortic aneurysms: parity, disparity, and switch.
Review in Journal of cardiac surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Smooth Muscle Cell Plasticity as a Central Determinant of Plaque Stability.Current atherosclerosis reports · 2026Review
- Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity.International journal of molecular sciences · 2026Article
- New Directions in Diagnostics for Aortic Aneurysms: Biomarkers and Machine Learning.Journal of clinical medicine · 2024Review
- Article
- The Role and Mechanism of SIRT6 in Regulating Phenotype Transformation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm.Computational and mathematical methods in medicine · 2022Article
- A validated mouse model capable of recapitulating the protective effects of female sex hormones on ascending aortic aneurysms and dissections (AADs).Physiological reports · 2020Article
- Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm.American journal of physiology. Heart and circulatory physiology · 2020Review
- Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Mapping Semaphorins and Netrins in the Pathogenesis of Human Thoracic Aortic Aneurysms.International journal of molecular sciences · 2019Article
- TLR4 and MMP2 polymorphisms and their associations with cardiovascular risk factors in susceptibility to aortic aneurysmal diseases.Bioscience reports · 2019Article
- The genetics and biomechanics of thoracic aortic diseases.Vascular biology (Bristol, England) · 2019Review
- Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms.International journal of vascular medicine · 2016Article
- Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm.BioMed research international · 2015Article
- Inhibition of interleukin-1β decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms.Circulation · 2014Article
- MicroRNA-21 inhibits platelet-derived growth factor-induced human aortic vascular smooth muscle cell proliferation and migration through targeting activator protein-1.American journal of translational research · 2014Article
- Cathepsins: a new culprit behind abdominal aortic aneurysm.Regenerative medicine research · 2013Review
- Preliminary biomarkers for identification of human ascending thoracic aortic aneurysm.Journal of the American Heart Association · 2013Article
- Parametric study of effects of collagen turnover on the natural history of abdominal aortic aneurysms.Proceedings. Mathematical, physical, and engineering sciences · 2013Article
- Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β.Journal of vascular research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Central to the pathologic changes in developing aortic aneurysms are alterations in the abundance and activity of proteases, of which the most important for aneurysm production comprise the matrix metalloproteinase (MMP) family. In this review, literature demonstrating the role of MMPs in the development of aortic aneurysms is presented, with emphasis on the parity and disparity between the thoracic and abdominal aorta. Furthermore, the role of embryologic cellular origins and evidence of phenotypic switch will be addressed in terms of how this process alters MMP production during aneurysm development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.