ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Peptide neuromodulation of synaptic dynamics in an oscillatory network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Neuropeptide Modulation Enables Biphasic Internetwork Coordination via a Dual-Network Neuron.eNeuro · 2024Article
- Switching neuron contributions to second network activity.Journal of neurophysiology · 2024Article
- Modulation by Neuropeptides with Overlapping Targets Results in Functional Overlap in Oscillatory Circuit Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Regimes and mechanisms of transient amplification in abstract and biological neural networks.PLoS computational biology · 2022Article
- Neuromodulation Enables Temperature Robustness and Coupling Between Fast and Slow Oscillator Circuits.Frontiers in cellular neuroscience · 2022Article
- Neuropeptide Modulation Increases Dendritic Electrical Spread to Restore Neuronal Activity Disrupted by Temperature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Background calcium induced by subthreshold depolarization modifies homosynaptic facilitation at a synapse in Aplysia.Scientific reports · 2020Article
- The differential contribution of pacemaker neurons to synaptic transmission in the pyloric network of the Jonah crab,Journal of neurophysiology · 2019Article
- Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network.eLife · 2019Article
- The Mechanistic Basis for Successful Spinal Cord Stimulation to Generate Steady Motor Outputs.Frontiers in cellular neuroscience · 2019Article
- Article
- Graded Transmission without Action Potentials Sustains Rhythmic Activity in Some But Not All Modulators That Activate the Same Current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Distinct Co-Modulation Rules of Synapses and Voltage-Gated Currents Coordinate Interactions of Multiple Neuromodulators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Activation mechanism of a neuromodulator-gated pacemaker ionic current.Journal of neurophysiology · 2017Article
- Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms.Developmental neurobiology · 2017Review
- The Lesioned Spinal Cord Is a "New" Spinal Cord: Evidence from Functional Changes after Spinal Injury in Lamprey.Frontiers in neural circuits · 2017Review
- Network feedback regulates motor output across a range of modulatory neuron activity.Journal of neurophysiology · 2016Article
- Convergent neuromodulation onto a network neuron can have divergent effects at the network level.Journal of computational neuroscience · 2016Article
- Neuropeptide receptor transcript expression levels and magnitude of ionic current responses show cell type-specific differences in a small motor circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Although neuromodulation of synapses is extensively documented, its consequences in the context of network oscillations are not well known. We examine the modulation of synaptic strength and short-term dynamics in the crab pyloric network by the neuropeptide proctolin. Pyloric oscillations are driven by a pacemaker group which receives feedback through the inhibitory synapse from the lateral pyloric (LP) to pyloric dilator (PD) neurons. We show that proctolin modulates the spike-mediated and graded components of the LP to PD synapse. Proctolin enhances the graded component and unmasks a surprising heterogeneity in its dynamics where there is depression or facilitation depending on the amplitude of the voltage waveform of the presynaptic LP neuron. The spike-mediated component is influenced by the baseline membrane potential and is also enhanced by proctolin at all baseline potentials. In addition to direct modulation of this synapse, proctolin also changes the shape and amplitude of the presynaptic voltage waveform which additionally enhances synaptic output during ongoing activity. During ongoing oscillations, proctolin reduces the variability of cycle period but only when the LP to PD synapse is functionally intact. Using the dynamic clamp technique we find that the reduction in variability is a direct consequence of modulation of the LP to PD synapse. These results demonstrate that neuromodulation of synapses involves complex and interacting influences that target different synaptic components and dynamics as well as the presynaptic voltage waveform. At the network level, modulation of feedback inhibition can result in reduction of variability and enhancement of stable oscillatory output.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.