ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Sleep facilitates pattern separation through SK channel-mediated sparse coding.Current biology : CB · 2026Article
- Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.Nature neuroscience · 2026Article
- Investigating the immunomodulatory effects of honeybee venom peptide apamin inInfection and immunity · 2025Article
- Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.The European journal of neuroscience · 2025Article
- Intermediate conductance CaFrontiers in insect science · 2022Article
- Slo2/KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Age-related changes in Kv4/Shal and Kv1/Shaker expression in Drosophila and a role for reactive oxygen species.PloS one · 2021Article
- Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Modulation of voltage-dependent K+ conductances in photoreceptors trades off investment in contrast gain for bandwidth.PLoS computational biology · 2018Article
- The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception.Cell reports · 2018Article
- On the role of transient depolarization-activated KThe Journal of general physiology · 2018Article
- Article
- How a fly photoreceptor samples light information in time.The Journal of physiology · 2017Review
- Electrophysiological Method for Recording Intracellular Voltage Responses of Drosophila Photoreceptors and Interneurons to Light Stimuli In Vivo.Journal of visualized experiments : JoVE · 2016Article
- Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons.Journal of neurophysiology · 2016Article
- Intrinsic and Network Mechanisms Constrain Neural Synchrony in the Moth Antennal Lobe.Frontiers in physiology · 2016Article
- Evidence for Dynamic Network Regulation of Drosophila Photoreceptor Function from Mutants Lacking the Neurotransmitter Histamine.Frontiers in neural circuits · 2016Article
- Modeling the cellular mechanisms and olfactory input underlying the triphasic response of moth pheromone-sensitive projection neurons.PloS one · 2015Article
- Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ.Journal of neurophysiology · 2014Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
The contribution of the SK (small-conductance calcium-activated potassium) channel to neuronal functions in complex circuits underlying sensory processing and behavior is largely unknown in the absence of suitable animal models. Here, we generated a Drosophila line that lacks the single highly conserved SK gene in its genome (dSK). In R1-R6 photoreceptors, dSK encodes a slow Ca²⁺-activated K(+) current similar to its mammalian counterparts. Compared with wild-type, dSK(-) photoreceptors and interneurons showed accelerated oscillatory responses and adaptation. These enhanced kinetics were accompanied with more depolarized dSK(-) photoreceptors axons, assigning a role for dSK in network gain control during light-to-dark transitions. However, compensatory network adaptation, through increasing activity between synaptic neighbors, overcame many detriments of missing dSK current enabling dSK(-) photoreceptors to maintain normal information transfer rates to naturalistic stimuli. While demonstrating important functional roles for dSK channel in the visual circuitry, these results also clarify how homeostatically balanced network functions can compensate missing or faulty ion channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.