ArticleJournal of neurophysiology2012
Persistent activity in a cortical-to-subcortical circuit: bridging the temporal gap in trace eyelid conditioning.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60 citing papers in PubMed, 84 citations in OpenAlex.
- Self-timed movement initiation requires rapid sequential coordination of circuits in prefrontal cortex and cerebellum.bioRxiv : the preprint server for biology · 2026Article
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- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Activity map of a cortico-cerebellar loop underlying motor planning.Nature neuroscience · 2023Article
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- Neural bases of freedom and responsibility.Frontiers in neural circuits · 2023Review
- Prefrontal projections to the nucleus reuniens signal behavioral relevance of stimuli during associative learning.Scientific reports · 2022Article
- Ventromedial Thalamus-Projecting DCN Neurons Modulate Associative Sensorimotor Responses in Mice.Neuroscience bulletin · 2022Article
- Functional properties of eyelid conditioned responses and involved brain centers.Frontiers in behavioral neuroscience · 2022Review
- Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice.Neuroscience bulletin · 2021Article
- Bidirectional learning in upbound and downbound microzones of the cerebellum.Nature reviews. Neuroscience · 2021Review
- Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner.Frontiers in neural circuits · 2021Article
- Cortico-cerebellar interactions during goal-directed behavior.Current opinion in neurobiology · 2020Review
- Visual Sequences Drive Experience-Dependent Plasticity in Mouse Anterior Cingulate Cortex.Cell reports · 2020Article
- Hippocampal and lateral entorhinal cortex physiological activity during trace conditioning under urethane anesthesia.Journal of neurophysiology · 2020Article
- Ventral Hippocampal Input to the Prelimbic Cortex Dissociates the Context from the Cue Association in Trace Fear Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Distributed representations of temporal stimulus associations across regular-firing and fast-spiking neurons in rat medial prefrontal cortex.Journal of neurophysiology · 2020Article
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4 authors at 1 institution in 1 country.
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Abstract
We have addressed the source and nature of the persistent neural activity that bridges the stimulus-free gap between the conditioned stimulus (CS) and unconditioned stimulus (US) during trace eyelid conditioning. Previous work has demonstrated that this persistent activity is necessary for trace eyelid conditioning: CS-elicited activity in mossy fiber inputs to the cerebellum does not extend into the stimulus-free trace interval, which precludes the cerebellar learning that mediates conditioned response expression. In behaving rabbits we used in vivo recordings from a region of medial prefrontal cortex (mPFC) that is necessary for trace eyelid conditioning to test the hypothesis that neurons there generate activity that persists beyond CS offset. These recordings revealed two patterns of activity during the trace interval that would enable cerebellar learning. Activity in some cells began during the tone CS and persisted to overlap with the US, whereas in other cells, activity began during the stimulus-free trace interval. Injection of anterograde tracers into this same region of mPFC revealed dense labeling in the pontine nuclei, where recordings also revealed tone-evoked persistent activity during trace conditioning. These data suggest a corticopontine pathway that provides an input to the cerebellum during trace conditioning trials that bridges the temporal gap between the CS and US to engage cerebellar learning. As such, trace eyelid conditioning represents a well-characterized and experimentally tractable system that can facilitate mechanistic analyses of cortical persistent activity and how it is used by downstream brain structures to influence behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.