ArticleAmerican journal of physiology. Renal physiology2012
Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Significance of methylation-related genes in diagnosis and subtype classification of renal interstitial fibrosis.Hereditas · 2023Article
- Accumulation of Renal Fibrosis in Hyperuricemia Rats Is Attributed to the Recruitment of Mast Cells, Activation of the TGF-β1/Smad2/3 Pathway, and Aggravation of Oxidative Stress.International journal of molecular sciences · 2023Article
- Pulmonary Protein Oxidation and Oxidative Stress Modulation byAntioxidants (Basel, Switzerland) · 2022Article
- Mast cells in the kidney biopsies of pediatric patients with lupus nephritis.Jornal brasileiro de nefrologia · 2020Article
- Delayed Rectifier KBioMed research international · 2019Article
- An Adaptogen: Withaferin A AmelioratesFrontiers in pharmacology · 2018Article
- Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction.Frontiers in immunology · 2017Article
- Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats.Journal of cardiovascular pharmacology · 2016Article
- Observational
- E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- What is the best way to measure renal fibrosis?: A pathologist's perspective.Kidney international supplements · 2014Review
- Inflammatory processes in renal fibrosis.Nature reviews. Nephrology · 2014Review
- Mast cells: a pivotal role in pulmonary fibrosis.DNA and cell biology · 2013Article
- Are mast cells instrumental for fibrotic diseases?Frontiers in pharmacology · 2013Review
- Renal interstitial fibrosis: mechanisms and evaluation.Current opinion in nephrology and hypertension · 2012Review
- Targeting cardiac mast cells: pharmacological modulation of the local renin-angiotensin system.Current pharmaceutical design · 2011Review
- Role of mast cells in the development of renal fibrosis: use of mast cell-deficient rats.Kidney international · 2004Article
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13 authors at 1 institution in 1 country.
Funding
Abstract
Mast cells are associated with inflammation and fibrosis. Whether they protect against or contribute to renal fibrosis is unclear. Based on our previous findings that mast cells can express and secrete active renin, and that angiotensin (ANG II) is profibrotic, we hypothesized that mast cells play a critical role in tubulointerstitial fibrosis. We tested this hypothesis in the 14-day unilateral ureteral obstruction (UUO) model in rats and mast cell-deficient (MCD) mice (WBB6F1-W/Wv) and their congenic controls (CC). In the 14-day UUO rat kidney, mast cell number is increased and they express active renin. Stabilizing mast cells in vivo with administration of cromolyn sodium attenuated the development of tubulointerstitial fibrosis, which was confirmed by measuring newly synthesized pepsin-soluble collagen and blind scoring of fixed trichrome-stained kidney sections accompanied by spectral analysis. Fibrosis was absent in UUO kidneys from MCD mice unlike that observed in the CC mice. Losartan treatment reduced the fibrosis in the CC UUO kidneys. The effects of mast cell degranulation and renin release were tested in the isolated, perfused kidney preparation. Mast cell degranulation led to renin-dependent protracted flow recovery. This demonstrates that mast cell renin is active in situ and the ensuing ANG II can modulate intrarenal vascular resistance in the UUO kidney. Collectively, the data demonstrate that mast cells are critical to the development of renal fibrosis in the 14-day UUO kidney. Since renin is present in human kidney mast cells, our work identifies potential targets in the treatment of renal fibrosis.
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