ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Evidence for the role of hindbrain orexin-1 receptors in the control of meal size.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats.Addiction neuroscience · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis.Frontiers in endocrinology · 2022Review
- The Orexin System: A Potential Player in the Pathophysiology of Absence Epilepsy.Current neuropharmacology · 2022Article
- The dynamic regulation of appetitive behavior through lateral hypothalamic orexin and melanin concentrating hormone expressing cells.Physiology & behavior · 2021Review
- Hindbrain orexin 1 receptors blunt intake suppression by gastrointestinal nutrients and cholecystokinin in male rats.Peptides · 2020Article
- The Effects of Mutual Interaction of Orexin-A and Glucagon-Like Peptide-1 on Reflex Swallowing Induced by SLN Afferents in Rats.International journal of molecular sciences · 2020Article
- Involvement of orexin/hypocretin in the expression of social play behaviour in juvenile rats.International journal of play · 2020Article
- Endocannabinoids in Body Weight Control.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons.Frontiers in psychiatry · 2018Review
- Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Ghrelin: A link between memory and ingestive behavior.Physiology & behavior · 2016Review
- Computational Analysis of the Hypothalamic Control of Food Intake.Frontiers in computational neuroscience · 2016Article
- Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways.eLife · 2015Article
- Orexin-A enhances feeding in male rats by activating hindbrain catecholamine neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Hindbrain Catecholamine Neurons Activate Orexin Neurons During Systemic Glucoprivation in Male Rats.Endocrinology · 2015Article
- Neural integration of satiation and food reward: role of GLP-1 and orexin pathways.Physiology & behavior · 2014Review
- Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats.Neuroscience letters · 2014Article
- Peripheral interleukin-2 level is associated with negative symptoms and cognitive performance in schizophrenia.Physiology & behavior · 2014Article
- Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats.Psychopharmacology · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hypothalamic orexin neurons project to the hindbrain, and 4th-ventricle intracerebroventricular (4th-icv) injection of orexin-A treatment increases food intake. We assessed the effects of hindbrain orexin-A and the orexin-1-receptor antagonist SB334867 on meal pattern in rats consuming standard chow. When injected 4th-icv shortly before dark onset, lower doses of orexin-A increased food intake over a 2-h period by increasing the size of the first meal relative to vehicle, whereas the highest dose increased food intake by causing the second meal to be taken sooner. Conversely, hindbrain SB334867 reduced food intake by decreasing the size of the first meal of the dark phase. We also examined the effects of 4th-icv orexin-A and SB334867 on locomotor activity. Only the highest dose of orexin-A increased activity, and SB334867 had no effect. In addition, hindbrain SB334867 induced c-Fos in the nucleus of the solitary tract. These data support the suggestion that endogenous hindbrain orexin-A acts to limit satiation. Both orexin-A and the pancreatic satiation hormone amylin require an intact area postrema to affect food intake, so we asked whether 4th-icv orexin-A impairs the satiating effect of peripheral amylin treatment. Amylin reduced the size of the first meal of the dark cycle when rats were pretreated with 4th-icv saline, yet amylin was ineffective after 4th-icv orexin-A pretreatment. Using double-label immunohistochemistry, we determined that some orexin-A fibers in the area postrema are located in proximity to amylin-responsive neurons. Therefore, hindbrain orexin-A may increase food intake, in part, by reducing the ability of rats to respond to amylin during a meal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.