ArticleJournal of the Royal Society, Interface2012
In-roads to the spread of antibiotic resistance: regional patterns of microbial transmission in northern coastal Ecuador.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Impact of Zika Emergence in Remote Communities in Northwestern Ecuador.The Journal of infectious diseases · 2024Article
- Road networks and socio-demographic factors to explore COVID-19 infection during its different waves.Scientific reports · 2024Article
- Population genomics of diarrheagenic Escherichia coli uncovers high connectivity between urban and rural communities in Ecuador.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023Article
- Epidemiology of antimicrobial resistance in bacteria isolated from inpatient and outpatient samples, Ecuador, 2018.Revista panamericana de salud publica = Pan American journal of public health · 2023Article
- A Chikungunya Outbreak in a Dengue-endemic Region in Rural Northern Coastal Ecuador.The American journal of tropical medicine and hygiene · 2022Article
- "Chicken dumping": Motivations and perceptions in shifting poultry production practices.One health (Amsterdam, Netherlands) · 2021Article
- Spatial relationships between small-holder farms coupled with livestock management practices are correlated with the distribution of antibiotic resistant bacteria in northern Tanzania.One health (Amsterdam, Netherlands) · 2019Article
- Impacts of small-scale chicken farming activity on antimicrobial-resistantOne health (Amsterdam, Netherlands) · 2019Article
- Assessing Transmission of Antimicrobial-ResistantApplied and environmental microbiology · 2019Article
- Identification of risk factors associated with carriage of resistant Escherichia coli in three culturally diverse ethnic groups in Tanzania: a biological and socioeconomic analysis.The Lancet. Planetary health · 2018Article
- The Role of Mobile Genetic Elements in the Spread of Antimicrobial-Resistant Escherichia coli From Chickens to Humans in Small-Scale Production Poultry Operations in Rural Ecuador.American journal of epidemiology · 2018Article
- Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis.Frontiers in microbiology · 2016Review
- Potential virulence of Klebsiella sp. isolates from enteral diets.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Experimental antibiotic treatment identifies potential pathogens of white band disease in the endangered Caribbean coral Acropora cervicornis.Proceedings. Biological sciences · 2014Article
- Resistant gram-negative infections in the outpatient setting in Latin America.Epidemiology and infection · 2013Review
- Transition in the cause of fever from malaria to dengue, Northwestern Ecuador, 1990-2011.Emerging infectious diseases · 2013Article
- How to make epidemiological training infectious.PLoS biology · 2012Article
- Article
- Detection and molecular characterization of β-lactamase genes in clinical isolates of Gram-negative bacteria in Southern Ecuador.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
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14 authors.
Funding
Abstract
The evolution of antibiotic resistance (AR) increases treatment cost and probability of failure, threatening human health worldwide. The relative importance of individual antibiotic use, environmental transmission and rates of introduction of resistant bacteria in explaining community AR patterns is poorly understood. Evaluating their relative importance requires studying a region where they vary. The construction of a new road in a previously roadless area of northern coastal Ecuador provides a valuable natural experiment to study how changes in the social and natural environment affect the epidemiology of resistant Escherichia coli. We conducted seven bi-annual 15 day surveys of AR between 2003 and 2008 in 21 villages. Resistance to both ampicillin and sulphamethoxazole was the most frequently observed profile, based on antibiogram tests of seven antibiotics from 2210 samples. The prevalence of enteric bacteria with this resistance pair in the less remote communities was 80 per cent higher than in more remote communities (OR = 1.8 [1.3, 2.3]). This pattern could not be explained with data on individual antibiotic use. We used a transmission model to help explain this observed discrepancy. The model analysis suggests that both transmission and the rate of introduction of resistant bacteria into communities may contribute to the observed regional scale AR patterns, and that village-level antibiotic use rate determines which of these two factors predominate. While usually conceived as a main effect on individual risk, antibiotic use rate is revealed in this analysis as an effect modifier with regard to community-level risk of resistance.
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