ArticleJournal of the Royal Society, Interface2012
Modulating protein adsorption onto hydroxyapatite particles using different amino acid treatments.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 92 citations in OpenAlex.
- Amino acid surface modified bioglass: A candidate biomaterial for bone tissue engineeringMicroscopy research and technique · 2025Article
- Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems.ACS biomaterials science & engineering · 2023Review
- Review
- Synthesis and Biological Properties of Alanine-Grafted Hydroxyapatite Nanoparticles.Life (Basel, Switzerland) · 2022Article
- Experimental Characterization and Mathematical Modeling of the Adsorption of Proteins and Cells on Biomimetic Hydroxyapatite.ACS omega · 2022Article
- Multifunctionality of Nanosized Calcium Apatite Dual-Doped with LiBiomolecules · 2021Article
- Viscosities of mixtures of hyaluronic acids with different molecular weights and their effects on enzymatic activities of lysozyme and peroxidase.Clinical oral investigations · 2020Article
- Structural and Chemical Hierarchy in Hydroxyapatite Coatings.Materials (Basel, Switzerland) · 2020Article
- L-Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X-Ray and Neutron Diffraction Study.ChemistryOpen · 2020Article
- Morphogen Delivery by Osteoconductive Nanoparticles Instructs Stromal Cell Spheroid Phenotype.Advanced biosystems · 2019Article
- The role of amino acids in hydroxyapatite mineralization.Journal of the Royal Society, Interface · 2016Review
- Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid.Journal of the Royal Society, Interface · 2016Article
- Priming the Surface of Orthopedic Implants for Osteoblast Attachment in Bone Tissue Engineering.International journal of medical sciences · 2015Review
- Enzyme-functionalized biomimetic apatites: concept and perspectives in view of innovative medical approaches.Journal of materials science. Materials in medicine · 2014Article
- Differentiation of human mesenchymal stem cells on plasma-treated polyetheretherketone.Journal of materials science. Materials in medicine · 2014Article
- Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxyapatite (HA) is a material of choice for bone grafts owing to its chemical and structural similarities to the mineral phase of hard tissues. The combination of osteogenic proteins with HA materials that carry and deliver the proteins to the bone-defective areas will accelerate bone regeneration. The study investigated the treatment of HA particles with different amino acids such as serine (Ser), asparagine (Asn), aspartic acid (Asp) and arginine (Arg) to enhance the adsorption ability of HA carrier for delivering therapeutic proteins to the body. The crystallinity of HA reduced when amino acids were added during HA preparation. Depending on the types of amino acid, the specific surface area of the amino acid-functionalized HA particles varied from 105 to 149 m(2) g(-1). Bovine serum albumin (BSA) and lysozyme were used as model proteins for adsorption study. The protein adsorption onto the surface of amino acid-functionalized HA depended on the polarities of HA particles, whereby, compared with lysozyme, BSA demonstrated higher affinity towards positively charged Arg-HA. Alternatively, the binding affinity of lysozyme onto the negatively charged Asp-HA was higher when compared with BSA. The BSA and lysozyme adsorptions onto the amino acid-functionalized HA fitted better into the Freundlich than Langmuir model. The amino acid-functionalized HA particles that had higher protein adsorption demonstrated a lower protein-release rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.